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Comparison of Two Assays to Determine Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis in relation to Other Chronic Inflammatory Rheumatic Diseases : Assaying Anti-Modified Citrullinated Vimentin Antibodies Adds Value to Second-Generation Anti-Citrullinated Cyclic Peptides Testing
المؤلفون المشاركون
Díaz-Toscano, Miriam Lizette
Cardona-Muñoz, Ernesto German
Fajardo-Robledo, Nicte Selene
Corona-Sanchez, Esther Guadalupe
Nava, Arnulfo
Ponce-Guarneros, Manuel
Zavaleta-Muñiz, Soraya Amali
Salazar-Paramo, Mario
Gonzalez-Lopez, Laura
Olivas-Flores, Eva Maria
Celis, Alfredo
Castro-Contreras, Uriel
Gamez-Nava, Jorge Ivan
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-15
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Determination of anti-citrullinated peptide antibodies (ACPA) plays a relevant role in the diagnosis of rheumatoid arthritis (RA).
To date, it is still unclear if the use of several tests for these autoantibodies in the same patient offers additional value as compared to performing only one test.
Therefore, we evaluated the performance of using two assays for ACPA: second-generation anti-citrullinated cyclic peptides antibodies (anti-CCP2) and anti-mutated citrullinated vimentin (anti-MCV) antibodies for the diagnosis of RA.
We compared three groups: RA (n=142), chronic inflammatory disease (CIRD, n=86), and clinically healthy subjects (CHS, n=56) to evaluate sensitivity, specificity, predictive values, and likelihood ratios (LR) of these two assays for the presence of RA.
A lower frequency of positivity for anti-CCP2 was found in RA (66.2%) as compared with anti-MCV (81.0%).
When comparing RA versus other CIRD, sensitivity increased when both assays were performed.
This strategy of testing both assays had high specificity and LR+.
We conclude that adding the assay of anti-MCV antibodies to the determination of anti-CCP2 increases the sensitivity for detecting seropositive RA.
Therefore, we propose the use of both assays in the initial screening of RA in longitudinal studies, including early onset of undifferentiated arthritis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Díaz-Toscano, Miriam Lizette& Olivas-Flores, Eva Maria& Zavaleta-Muñiz, Soraya Amali& Gamez-Nava, Jorge Ivan& Cardona-Muñoz, Ernesto German& Ponce-Guarneros, Manuel…[et al.]. 2014. Comparison of Two Assays to Determine Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis in relation to Other Chronic Inflammatory Rheumatic Diseases : Assaying Anti-Modified Citrullinated Vimentin Antibodies Adds Value to Second-Generation Anti-Citrullinated Cyclic Peptides Testing. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-453859
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Díaz-Toscano, Miriam Lizette…[et al.]. Comparison of Two Assays to Determine Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis in relation to Other Chronic Inflammatory Rheumatic Diseases : Assaying Anti-Modified Citrullinated Vimentin Antibodies Adds Value to Second-Generation Anti-Citrullinated Cyclic Peptides Testing. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-453859
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Díaz-Toscano, Miriam Lizette& Olivas-Flores, Eva Maria& Zavaleta-Muñiz, Soraya Amali& Gamez-Nava, Jorge Ivan& Cardona-Muñoz, Ernesto German& Ponce-Guarneros, Manuel…[et al.]. Comparison of Two Assays to Determine Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis in relation to Other Chronic Inflammatory Rheumatic Diseases : Assaying Anti-Modified Citrullinated Vimentin Antibodies Adds Value to Second-Generation Anti-Citrullinated Cyclic Peptides Testing. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-453859
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453859
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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