Comparison of Two Assays to Determine Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis in relation to Other Chronic Inflammatory Rheumatic Diseases : Assaying Anti-Modified Citrullinated Vimentin Antibodies Adds Value to Second-Generation Anti-Citrullinated Cyclic Peptides Testing
Joint Authors
Díaz-Toscano, Miriam Lizette
Cardona-Muñoz, Ernesto German
Fajardo-Robledo, Nicte Selene
Corona-Sanchez, Esther Guadalupe
Nava, Arnulfo
Ponce-Guarneros, Manuel
Zavaleta-Muñiz, Soraya Amali
Salazar-Paramo, Mario
Gonzalez-Lopez, Laura
Olivas-Flores, Eva Maria
Celis, Alfredo
Castro-Contreras, Uriel
Gamez-Nava, Jorge Ivan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Determination of anti-citrullinated peptide antibodies (ACPA) plays a relevant role in the diagnosis of rheumatoid arthritis (RA).
To date, it is still unclear if the use of several tests for these autoantibodies in the same patient offers additional value as compared to performing only one test.
Therefore, we evaluated the performance of using two assays for ACPA: second-generation anti-citrullinated cyclic peptides antibodies (anti-CCP2) and anti-mutated citrullinated vimentin (anti-MCV) antibodies for the diagnosis of RA.
We compared three groups: RA (n=142), chronic inflammatory disease (CIRD, n=86), and clinically healthy subjects (CHS, n=56) to evaluate sensitivity, specificity, predictive values, and likelihood ratios (LR) of these two assays for the presence of RA.
A lower frequency of positivity for anti-CCP2 was found in RA (66.2%) as compared with anti-MCV (81.0%).
When comparing RA versus other CIRD, sensitivity increased when both assays were performed.
This strategy of testing both assays had high specificity and LR+.
We conclude that adding the assay of anti-MCV antibodies to the determination of anti-CCP2 increases the sensitivity for detecting seropositive RA.
Therefore, we propose the use of both assays in the initial screening of RA in longitudinal studies, including early onset of undifferentiated arthritis.
American Psychological Association (APA)
Díaz-Toscano, Miriam Lizette& Olivas-Flores, Eva Maria& Zavaleta-Muñiz, Soraya Amali& Gamez-Nava, Jorge Ivan& Cardona-Muñoz, Ernesto German& Ponce-Guarneros, Manuel…[et al.]. 2014. Comparison of Two Assays to Determine Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis in relation to Other Chronic Inflammatory Rheumatic Diseases : Assaying Anti-Modified Citrullinated Vimentin Antibodies Adds Value to Second-Generation Anti-Citrullinated Cyclic Peptides Testing. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-453859
Modern Language Association (MLA)
Díaz-Toscano, Miriam Lizette…[et al.]. Comparison of Two Assays to Determine Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis in relation to Other Chronic Inflammatory Rheumatic Diseases : Assaying Anti-Modified Citrullinated Vimentin Antibodies Adds Value to Second-Generation Anti-Citrullinated Cyclic Peptides Testing. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-453859
American Medical Association (AMA)
Díaz-Toscano, Miriam Lizette& Olivas-Flores, Eva Maria& Zavaleta-Muñiz, Soraya Amali& Gamez-Nava, Jorge Ivan& Cardona-Muñoz, Ernesto German& Ponce-Guarneros, Manuel…[et al.]. Comparison of Two Assays to Determine Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis in relation to Other Chronic Inflammatory Rheumatic Diseases : Assaying Anti-Modified Citrullinated Vimentin Antibodies Adds Value to Second-Generation Anti-Citrullinated Cyclic Peptides Testing. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-453859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453859