Genes Associated with SLE Are Targets of Recent Positive Selection
المؤلفون المشاركون
Ward, Ralph C.
Langefeld, Carl D.
Ramos, Paula S.
Shaftman, Stephanie R.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-23
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The reasons for the ethnic disparities in the prevalence of systemic lupus erythematosus (SLE) and the relative high frequency of SLE risk alleles in the population are not fully understood.
Population genetic factors such as natural selection alter allele frequencies over generations and may help explain the persistence of such common risk variants in the population and the differential risk of SLE.
In order to better understand the genetic basis of SLE that might be due to natural selection, a total of 74 genomic regions with compelling evidence for association with SLE were tested for evidence of recent positive selection in the HapMap and HGDP populations, using population differentiation, allele frequency, and haplotype-based tests.
Consistent signs of positive selection across different studies and statistical methods were observed at several SLE-associated loci, including PTPN22, TNFSF4, TET3-DGUOK, TNIP1, UHRF1BP1, BLK, and ITGAM genes.
This study is the first to evaluate and report that several SLE-associated regions show signs of positive natural selection.
These results provide corroborating evidence in support of recent positive selection as one mechanism underlying the elevated population frequency of SLE risk loci and supports future research that integrates signals of natural selection to help identify functional SLE risk alleles.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ramos, Paula S.& Shaftman, Stephanie R.& Ward, Ralph C.& Langefeld, Carl D.. 2014. Genes Associated with SLE Are Targets of Recent Positive Selection. Autoimmune Diseases،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-454145
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ramos, Paula S.…[et al.]. Genes Associated with SLE Are Targets of Recent Positive Selection. Autoimmune Diseases No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-454145
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ramos, Paula S.& Shaftman, Stephanie R.& Ward, Ralph C.& Langefeld, Carl D.. Genes Associated with SLE Are Targets of Recent Positive Selection. Autoimmune Diseases. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-454145
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454145
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر