Genes Associated with SLE Are Targets of Recent Positive Selection
Joint Authors
Ward, Ralph C.
Langefeld, Carl D.
Ramos, Paula S.
Shaftman, Stephanie R.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The reasons for the ethnic disparities in the prevalence of systemic lupus erythematosus (SLE) and the relative high frequency of SLE risk alleles in the population are not fully understood.
Population genetic factors such as natural selection alter allele frequencies over generations and may help explain the persistence of such common risk variants in the population and the differential risk of SLE.
In order to better understand the genetic basis of SLE that might be due to natural selection, a total of 74 genomic regions with compelling evidence for association with SLE were tested for evidence of recent positive selection in the HapMap and HGDP populations, using population differentiation, allele frequency, and haplotype-based tests.
Consistent signs of positive selection across different studies and statistical methods were observed at several SLE-associated loci, including PTPN22, TNFSF4, TET3-DGUOK, TNIP1, UHRF1BP1, BLK, and ITGAM genes.
This study is the first to evaluate and report that several SLE-associated regions show signs of positive natural selection.
These results provide corroborating evidence in support of recent positive selection as one mechanism underlying the elevated population frequency of SLE risk loci and supports future research that integrates signals of natural selection to help identify functional SLE risk alleles.
American Psychological Association (APA)
Ramos, Paula S.& Shaftman, Stephanie R.& Ward, Ralph C.& Langefeld, Carl D.. 2014. Genes Associated with SLE Are Targets of Recent Positive Selection. Autoimmune Diseases،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-454145
Modern Language Association (MLA)
Ramos, Paula S.…[et al.]. Genes Associated with SLE Are Targets of Recent Positive Selection. Autoimmune Diseases No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-454145
American Medical Association (AMA)
Ramos, Paula S.& Shaftman, Stephanie R.& Ward, Ralph C.& Langefeld, Carl D.. Genes Associated with SLE Are Targets of Recent Positive Selection. Autoimmune Diseases. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-454145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454145