Antitumoral Activity of Snake Venom Proteins : New Trends in Cancer Therapy
المؤلفون المشاركون
Zuliani, Juliana P.
Mazzi, Maurício V.
da Silva, Saulo Luís
Nomizo, Auro
Grabner, Amy N.
Stábeli, Rodrigo G.
Marcussi, Silvana
de Moura, Andrea A.
Calderon, Leonardo A.
Soares, Andreimar Martins
Zaqueo, Kayena D.
Carvalho, Bruna M. A.
Sobrinho, Juliana C.
Fernandes, Carla F. C.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-13
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
For more than half a century, cytotoxic agents have been investigated as a possible treatment for cancer.
Research on animal venoms has revealed their high toxicity on tissues and cell cultures, both normal and tumoral.
Snake venoms show the highest cytotoxic potential, since ophidian accidents cause a large amount of tissue damage, suggesting a promising utilization of these venoms or their components as antitumoral agents.
Over the last few years, we have studied the effects of snake venoms and their isolated enzymes on tumor cell cultures.
Some in vivo assays showed antineoplastic activity against induced tumors in mice.
In human beings, both the crude venom and isolated enzymes revealed antitumor activities in preliminary assays, with measurable clinical responses in the advanced treatment phase.
These enzymes include metalloproteases (MP), disintegrins, L-amino acid oxidases (LAAOs), C-type lectins, and phospholipases A2 (PLA2s).
Their mechanisms of action include direct toxic action (PLA2s), free radical generation (LAAOs), apoptosis induction (PLA2s, MP, and LAAOs), and antiangiogenesis (disintegrins and lectins).
Higher cytotoxic and cytostatic activities upon tumor cells than normal cells suggest the possibility for clinical applications.
Further studies should be conducted to ensure the efficacy and safety of different snake venom compounds for cancer drug development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Calderon, Leonardo A.& Sobrinho, Juliana C.& Zaqueo, Kayena D.& de Moura, Andrea A.& Grabner, Amy N.& Mazzi, Maurício V.…[et al.]. 2014. Antitumoral Activity of Snake Venom Proteins : New Trends in Cancer Therapy. BioMed Research International،Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-454174
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Calderon, Leonardo A.…[et al.]. Antitumoral Activity of Snake Venom Proteins : New Trends in Cancer Therapy. BioMed Research International No. 2014 (2014), pp.1-19.
https://search.emarefa.net/detail/BIM-454174
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Calderon, Leonardo A.& Sobrinho, Juliana C.& Zaqueo, Kayena D.& de Moura, Andrea A.& Grabner, Amy N.& Mazzi, Maurício V.…[et al.]. Antitumoral Activity of Snake Venom Proteins : New Trends in Cancer Therapy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-454174
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454174
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر