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Antitumoral Activity of Snake Venom Proteins : New Trends in Cancer Therapy
Joint Authors
Zuliani, Juliana P.
Mazzi, Maurício V.
da Silva, Saulo Luís
Nomizo, Auro
Grabner, Amy N.
Stábeli, Rodrigo G.
Marcussi, Silvana
de Moura, Andrea A.
Calderon, Leonardo A.
Soares, Andreimar Martins
Zaqueo, Kayena D.
Carvalho, Bruna M. A.
Sobrinho, Juliana C.
Fernandes, Carla F. C.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-13
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
For more than half a century, cytotoxic agents have been investigated as a possible treatment for cancer.
Research on animal venoms has revealed their high toxicity on tissues and cell cultures, both normal and tumoral.
Snake venoms show the highest cytotoxic potential, since ophidian accidents cause a large amount of tissue damage, suggesting a promising utilization of these venoms or their components as antitumoral agents.
Over the last few years, we have studied the effects of snake venoms and their isolated enzymes on tumor cell cultures.
Some in vivo assays showed antineoplastic activity against induced tumors in mice.
In human beings, both the crude venom and isolated enzymes revealed antitumor activities in preliminary assays, with measurable clinical responses in the advanced treatment phase.
These enzymes include metalloproteases (MP), disintegrins, L-amino acid oxidases (LAAOs), C-type lectins, and phospholipases A2 (PLA2s).
Their mechanisms of action include direct toxic action (PLA2s), free radical generation (LAAOs), apoptosis induction (PLA2s, MP, and LAAOs), and antiangiogenesis (disintegrins and lectins).
Higher cytotoxic and cytostatic activities upon tumor cells than normal cells suggest the possibility for clinical applications.
Further studies should be conducted to ensure the efficacy and safety of different snake venom compounds for cancer drug development.
American Psychological Association (APA)
Calderon, Leonardo A.& Sobrinho, Juliana C.& Zaqueo, Kayena D.& de Moura, Andrea A.& Grabner, Amy N.& Mazzi, Maurício V.…[et al.]. 2014. Antitumoral Activity of Snake Venom Proteins : New Trends in Cancer Therapy. BioMed Research International،Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-454174
Modern Language Association (MLA)
Calderon, Leonardo A.…[et al.]. Antitumoral Activity of Snake Venom Proteins : New Trends in Cancer Therapy. BioMed Research International No. 2014 (2014), pp.1-19.
https://search.emarefa.net/detail/BIM-454174
American Medical Association (AMA)
Calderon, Leonardo A.& Sobrinho, Juliana C.& Zaqueo, Kayena D.& de Moura, Andrea A.& Grabner, Amy N.& Mazzi, Maurício V.…[et al.]. Antitumoral Activity of Snake Venom Proteins : New Trends in Cancer Therapy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-454174
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454174