![](/images/graphics-bg.png)
Amelioration of Colitis in Mouse Model by Exploring Antioxidative Potentials of an Indigenous Probiotic Strain of Lactobacillus fermentum Lf1
المؤلفون المشاركون
Duary, Raj Kumar
Batish, Virender Kumar
Panwar, Harsh
Sudhakaran Vasanthakumari, Aparna
Mallapa, Rashmi H.
Grover, Sunita
Chauhan, Ritu
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-01
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Based on the preliminary screening of eight indigenous putative probiotic Lactobacilli, Lactobacillus fermentum Lf1 was selected for assessing its antioxidative efficacy in DSS colitis mouse model based on its ability to enhance the expression of “Nrf2” by 6.43-fold and malondialdehyde (MDA) inhibition by 78.1 ± 0.24% in HT-29 cells under H2O2 stress.
The Disease Activity Index and histological scores of Lf1-treated mice were lower than the control group.
However, expression of “Nrf2” was not observed in Lf1-treated mice.
A significant increase in the expression of antioxidative enzymes such as SOD2 and TrxR-1 was recorded in both of the groups.
The expression of SOD2 was significantly downregulated in colitis-induced mice by −100.00-fold relative to control group, and the downregulation was considerably reduced to −37.04-fold in colitis Lf1 treatment group.
Almost, a similar trend was recorded in case of “thioredoxin” expression, though “CAT” was refractile to expression.
The Lf1-treated group had decreased malondialdehyde level as compared to colitis control (37.92 ± 6.31 versus 91.13 ± 5.76 μM/g).
These results point towards Lf1-induced activation of the antioxidant enzyme system in the mouse model and its prospects to be explored as a new strategy for IBD management.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chauhan, Ritu& Sudhakaran Vasanthakumari, Aparna& Panwar, Harsh& Mallapa, Rashmi H.& Duary, Raj Kumar& Batish, Virender Kumar…[et al.]. 2014. Amelioration of Colitis in Mouse Model by Exploring Antioxidative Potentials of an Indigenous Probiotic Strain of Lactobacillus fermentum Lf1. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-454473
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chauhan, Ritu…[et al.]. Amelioration of Colitis in Mouse Model by Exploring Antioxidative Potentials of an Indigenous Probiotic Strain of Lactobacillus fermentum Lf1. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-454473
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chauhan, Ritu& Sudhakaran Vasanthakumari, Aparna& Panwar, Harsh& Mallapa, Rashmi H.& Duary, Raj Kumar& Batish, Virender Kumar…[et al.]. Amelioration of Colitis in Mouse Model by Exploring Antioxidative Potentials of an Indigenous Probiotic Strain of Lactobacillus fermentum Lf1. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-454473
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454473
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)