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Amelioration of Colitis in Mouse Model by Exploring Antioxidative Potentials of an Indigenous Probiotic Strain of Lactobacillus fermentum Lf1
Joint Authors
Duary, Raj Kumar
Batish, Virender Kumar
Panwar, Harsh
Sudhakaran Vasanthakumari, Aparna
Mallapa, Rashmi H.
Grover, Sunita
Chauhan, Ritu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Based on the preliminary screening of eight indigenous putative probiotic Lactobacilli, Lactobacillus fermentum Lf1 was selected for assessing its antioxidative efficacy in DSS colitis mouse model based on its ability to enhance the expression of “Nrf2” by 6.43-fold and malondialdehyde (MDA) inhibition by 78.1 ± 0.24% in HT-29 cells under H2O2 stress.
The Disease Activity Index and histological scores of Lf1-treated mice were lower than the control group.
However, expression of “Nrf2” was not observed in Lf1-treated mice.
A significant increase in the expression of antioxidative enzymes such as SOD2 and TrxR-1 was recorded in both of the groups.
The expression of SOD2 was significantly downregulated in colitis-induced mice by −100.00-fold relative to control group, and the downregulation was considerably reduced to −37.04-fold in colitis Lf1 treatment group.
Almost, a similar trend was recorded in case of “thioredoxin” expression, though “CAT” was refractile to expression.
The Lf1-treated group had decreased malondialdehyde level as compared to colitis control (37.92 ± 6.31 versus 91.13 ± 5.76 μM/g).
These results point towards Lf1-induced activation of the antioxidant enzyme system in the mouse model and its prospects to be explored as a new strategy for IBD management.
American Psychological Association (APA)
Chauhan, Ritu& Sudhakaran Vasanthakumari, Aparna& Panwar, Harsh& Mallapa, Rashmi H.& Duary, Raj Kumar& Batish, Virender Kumar…[et al.]. 2014. Amelioration of Colitis in Mouse Model by Exploring Antioxidative Potentials of an Indigenous Probiotic Strain of Lactobacillus fermentum Lf1. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-454473
Modern Language Association (MLA)
Chauhan, Ritu…[et al.]. Amelioration of Colitis in Mouse Model by Exploring Antioxidative Potentials of an Indigenous Probiotic Strain of Lactobacillus fermentum Lf1. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-454473
American Medical Association (AMA)
Chauhan, Ritu& Sudhakaran Vasanthakumari, Aparna& Panwar, Harsh& Mallapa, Rashmi H.& Duary, Raj Kumar& Batish, Virender Kumar…[et al.]. Amelioration of Colitis in Mouse Model by Exploring Antioxidative Potentials of an Indigenous Probiotic Strain of Lactobacillus fermentum Lf1. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-454473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454473