Identification of Differentially Expressed Gene after Femoral Fracture via Microarray Profiling
المؤلف
المصدر
International Journal of Genomics
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
We aimed to investigate differentially expressed genes (DEGs) in different stages after femoral fracture based on rat models, providing the basis for the treatment of sport-related fractures.
Gene expression data GSE3298 was downloaded from Gene Expression Omnibus (GEO), including 16 chips.
All femoral fracture samples were classified into earlier fracture stage and later fracture stage.
Total 87 DEGs simultaneously occurred in two stages, of which 4 genes showed opposite expression tendency.
Out of the 4 genes, Rest and Cst8 were hub nodes in protein-protein interaction (PPI) network.
The GO (Gene Ontology) function enrichment analysis verified that nutrition supply related genes were enriched in the earlier stage and neuron growth related genes were enriched in the later stage.
Calcium signaling pathway was the most significant pathway in earlier stage; in later stage, DEGs were enriched into 2 neurodevelopment-related pathways.
Analysis of Pearson's correlation coefficient showed that a total of 3,300 genes were significantly associated with fracture time, none of which was overlapped with identified DEGs.
This study suggested that Rest and Cst8 might act as potential indicators for fracture healing.
Calcium signaling pathway and neurodevelopment-related pathways might be deeply involved in bone healing after femoral fracture.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhong, Donggen. 2014. Identification of Differentially Expressed Gene after Femoral Fracture via Microarray Profiling. International Journal of Genomics،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-454681
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhong, Donggen. Identification of Differentially Expressed Gene after Femoral Fracture via Microarray Profiling. International Journal of Genomics No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-454681
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhong, Donggen. Identification of Differentially Expressed Gene after Femoral Fracture via Microarray Profiling. International Journal of Genomics. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-454681
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454681
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر