Estimation of True Serum Thyroglobulin Concentration Using Simultaneous Measurement of Serum Antithyroglobulin Antibody
المؤلفون المشاركون
Ahn, Byeong-Cheol
Lee, Won Kee
Jeong, Shin Young
Lee, Jaetae
Lee, Sang-Woo
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
We investigated the analytical interference of antithyroglobulin antibody (TgAb) to thyroglobulin (Tg) measurement and tried to convert measured Tg concentration to true Tg concentration using a mathematical equation which includes a concentration of TgAb.
Methods.
Tg was measured by immunoradiometric assay and TgAb by radioimmunoassy.
Experimental samples were produced by mixing Tg and TgAb standard solutions or mixing patients’ serum with high Tg or high TgAb.
Mathematical equations for prediction of expected Tg concentration with measured Tg and TgAb concentrations were deduced.
The Tg concentration calculated using the equations was compared with the expected Tg concentration.
Results.
Measured Tg concentrations of samples having high TgAb were significantly lower than their expected Tg concentration.
Magnitude of TgAb interference with the Tg assay showed a positive correlation with concentration of TgAb.
Mathematical equations for estimation of expected Tg concentration using measured Tg and TgAb concentrations were successfully deduced and the calculated Tg concentration showed excellent correlation with expected Tg concentration.
Conclusions.
A mathematic equation for estimation of true Tg concentration using measured Tg and TgAb concentration was deduced.
Tg concentration calculated by use of the equation might be more valuable than measured Tg concentration in patients with differentiated thyroid cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahn, Byeong-Cheol& Lee, Won Kee& Jeong, Shin Young& Lee, Sang-Woo& Lee, Jaetae. 2013. Estimation of True Serum Thyroglobulin Concentration Using Simultaneous Measurement of Serum Antithyroglobulin Antibody. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-454855
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahn, Byeong-Cheol…[et al.]. Estimation of True Serum Thyroglobulin Concentration Using Simultaneous Measurement of Serum Antithyroglobulin Antibody. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-454855
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahn, Byeong-Cheol& Lee, Won Kee& Jeong, Shin Young& Lee, Sang-Woo& Lee, Jaetae. Estimation of True Serum Thyroglobulin Concentration Using Simultaneous Measurement of Serum Antithyroglobulin Antibody. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-454855
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454855
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر