Estimation of True Serum Thyroglobulin Concentration Using Simultaneous Measurement of Serum Antithyroglobulin Antibody
Joint Authors
Ahn, Byeong-Cheol
Lee, Won Kee
Jeong, Shin Young
Lee, Jaetae
Lee, Sang-Woo
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We investigated the analytical interference of antithyroglobulin antibody (TgAb) to thyroglobulin (Tg) measurement and tried to convert measured Tg concentration to true Tg concentration using a mathematical equation which includes a concentration of TgAb.
Methods.
Tg was measured by immunoradiometric assay and TgAb by radioimmunoassy.
Experimental samples were produced by mixing Tg and TgAb standard solutions or mixing patients’ serum with high Tg or high TgAb.
Mathematical equations for prediction of expected Tg concentration with measured Tg and TgAb concentrations were deduced.
The Tg concentration calculated using the equations was compared with the expected Tg concentration.
Results.
Measured Tg concentrations of samples having high TgAb were significantly lower than their expected Tg concentration.
Magnitude of TgAb interference with the Tg assay showed a positive correlation with concentration of TgAb.
Mathematical equations for estimation of expected Tg concentration using measured Tg and TgAb concentrations were successfully deduced and the calculated Tg concentration showed excellent correlation with expected Tg concentration.
Conclusions.
A mathematic equation for estimation of true Tg concentration using measured Tg and TgAb concentration was deduced.
Tg concentration calculated by use of the equation might be more valuable than measured Tg concentration in patients with differentiated thyroid cancer.
American Psychological Association (APA)
Ahn, Byeong-Cheol& Lee, Won Kee& Jeong, Shin Young& Lee, Sang-Woo& Lee, Jaetae. 2013. Estimation of True Serum Thyroglobulin Concentration Using Simultaneous Measurement of Serum Antithyroglobulin Antibody. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-454855
Modern Language Association (MLA)
Ahn, Byeong-Cheol…[et al.]. Estimation of True Serum Thyroglobulin Concentration Using Simultaneous Measurement of Serum Antithyroglobulin Antibody. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-454855
American Medical Association (AMA)
Ahn, Byeong-Cheol& Lee, Won Kee& Jeong, Shin Young& Lee, Sang-Woo& Lee, Jaetae. Estimation of True Serum Thyroglobulin Concentration Using Simultaneous Measurement of Serum Antithyroglobulin Antibody. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-454855
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454855