AP-1IRF-3 Targeted Anti-Inflammatory Activity of Andrographolide Isolated from Andrographis paniculata
المؤلفون المشاركون
Shen, Ting
Yang, Woo Seok
Yi, Young-Su
Kim, Mi-Yeon
Kim, Jong Heon
Kim, Kyung-Woon
Poo, Haryoung
Cho, Jae Youl
Rhee, Man Hee
Sung, Gi-Ho
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-06
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Andrographolide (AG) is an abundant component of plants of the genus Andrographis and has a number of beneficial properties including neuroprotective, anticancer, anti-inflammatory, and antidiabetic effects.
Despite numerous pharmacological studies, the precise mechanism of AG is still ambiguous.
Thus, in the present study, we investigated the molecular mechanisms of AG and its target proteins as they pertain to anti-inflammatory responses.
AG suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2), as well as the mRNA abundance of inducible NO synthase (iNOS), tumor necrosis factor-alpha (TNF-α), cyclooxygenase (COX)-2, and interferon-beta (IFN-β) in a dose-dependent manner in both lipopolysaccharide- (LPS-) activated RAW264.7 cells and peritoneal macrophages.
AG also substantially ameliorated the symptoms of LPS-induced hepatitis and EtOH/HCl-induced gastritis in mice.
Based on the results of luciferase reporter gene assays, kinase assays, and measurement of nuclear levels of transcription factors, the anti-inflammatory effects of AG were found to be clearly mediated by inhibition of both (1) extracellular signal-regulated kinase (ERK)/activator protein (AP)-1 and (2) IκB kinase ε (IKKε)/interferon regulatory factor (IRF)-3 pathways.
In conclusion, we detected a novel molecular signaling pathway by which AG can suppress inflammatory responses.
Thus, AG is a promising anti-inflammatory drug with two pharmacological targets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shen, Ting& Yang, Woo Seok& Yi, Young-Su& Sung, Gi-Ho& Rhee, Man Hee& Poo, Haryoung…[et al.]. 2013. AP-1IRF-3 Targeted Anti-Inflammatory Activity of Andrographolide Isolated from Andrographis paniculata. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-454866
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shen, Ting…[et al.]. AP-1IRF-3 Targeted Anti-Inflammatory Activity of Andrographolide Isolated from Andrographis paniculata. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-454866
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shen, Ting& Yang, Woo Seok& Yi, Young-Su& Sung, Gi-Ho& Rhee, Man Hee& Poo, Haryoung…[et al.]. AP-1IRF-3 Targeted Anti-Inflammatory Activity of Andrographolide Isolated from Andrographis paniculata. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-454866
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454866
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر