Enhanced Neural Cell Adhesion and Neurite Outgrowth on Graphene-Based Biomimetic Substrates
المؤلفون المشاركون
Hong, Suck Won
Lee, Jong Ho
Han, Dong-Wook
Lee, Mi Hee
Hwang, Yu-Shik
Hwang, Eun Young
Kang, Seok Hee
Park, Jong-Chul
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Neural cell adhesion and neurite outgrowth were examined on graphene-based biomimetic substrates.
The biocompatibility of carbon nanomaterials such as graphene and carbon nanotubes (CNTs), that is, single-walled and multiwalled CNTs, against pheochromocytoma-derived PC-12 neural cells was also evaluated by quantifying metabolic activity (with WST-8 assay), intracellular oxidative stress (with ROS assay), and membrane integrity (with LDH assay).
Graphene films were grown by using chemical vapor deposition and were then coated onto glass coverslips by using the scooping method.
Graphene sheets were patterned on SiO2/Si substrates by using photolithography and were then covered with serum for a neural cell culture.
Both types of CNTs induced significant dose-dependent decreases in the viability of PC-12 cells, whereas graphene exerted adverse effects on the neural cells just at over 62.5 ppm.
This result implies that graphene and CNTs, even though they were the same carbon-based nanomaterials, show differential influences on neural cells.
Furthermore, graphene-coated or graphene-patterned substrates were shown to substantially enhance the adhesion and neurite outgrowth of PC-12 cells.
These results suggest that graphene-based substrates as biomimetic cues have good biocompatibility as well as a unique surface property that can enhance the neural cells, which would open up enormous opportunities in neural regeneration and nanomedicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hong, Suck Won& Lee, Jong Ho& Kang, Seok Hee& Hwang, Eun Young& Hwang, Yu-Shik& Lee, Mi Hee…[et al.]. 2014. Enhanced Neural Cell Adhesion and Neurite Outgrowth on Graphene-Based Biomimetic Substrates. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-454906
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hong, Suck Won…[et al.]. Enhanced Neural Cell Adhesion and Neurite Outgrowth on Graphene-Based Biomimetic Substrates. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-454906
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hong, Suck Won& Lee, Jong Ho& Kang, Seok Hee& Hwang, Eun Young& Hwang, Yu-Shik& Lee, Mi Hee…[et al.]. Enhanced Neural Cell Adhesion and Neurite Outgrowth on Graphene-Based Biomimetic Substrates. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-454906
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454906
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر