Recovery of the Cell Cycle Inhibition in CCl4-Induced Cirrhosis by the Adenosine Derivative IFC-305
المؤلفون المشاركون
Velasco-Loyden, Gabriela
Hernández-Muñoz, Rolando
Chagoya de Sánchez, Victoria
Martínez-Pérez, Lidia
المصدر
International Journal of Hepatology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Introduction.
Cirrhosis is a chronic degenerative illness characterized by changes in normal liver architecture, failure of hepatic function, and impairment of proliferative activity.
The aim of this study is to know how IFC-305 compound induces proliferation of the liver during reversion of cirrhosis.
Methods.
Once cirrhosis has been installed by CCl4 treatment for 10 weeks in male Wistar rats, they were divided into four groups: two received saline and two received the compound; all were euthanized at 5 and 10 weeks of treatment.
Liver homogenate, mitochondria, and nucleus were used to measure cyclins, CDKs, and cell cycle regulatory proteins PCNA, pRb, p53, E2F, p21, p27, HGF, liver ATP, and mitochondrial function.
Results.
Diminution and small changes were observed in the studied proteins in the cirrhotic animals without treatment.
The IFC-305-treated rats showed a clear increase in most of the proteins studied mainly in PCNA and CDK6, and a marked increased in ATP and mitochondrial function.
Discussion/Conclusion.
IFC-305 induces a recovery of the cell cycle inhibition promoting recovery of DNA damage through the action of PCNA and p53.
The increase in energy and preservation of mitochondrial function contribute to recovering the proliferative function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chagoya de Sánchez, Victoria& Martínez-Pérez, Lidia& Hernández-Muñoz, Rolando& Velasco-Loyden, Gabriela. 2012. Recovery of the Cell Cycle Inhibition in CCl4-Induced Cirrhosis by the Adenosine Derivative IFC-305. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-454937
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chagoya de Sánchez, Victoria…[et al.]. Recovery of the Cell Cycle Inhibition in CCl4-Induced Cirrhosis by the Adenosine Derivative IFC-305. International Journal of Hepatology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-454937
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chagoya de Sánchez, Victoria& Martínez-Pérez, Lidia& Hernández-Muñoz, Rolando& Velasco-Loyden, Gabriela. Recovery of the Cell Cycle Inhibition in CCl4-Induced Cirrhosis by the Adenosine Derivative IFC-305. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-454937
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454937
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر