Recovery of the Cell Cycle Inhibition in CCl4-Induced Cirrhosis by the Adenosine Derivative IFC-305
Joint Authors
Velasco-Loyden, Gabriela
Hernández-Muñoz, Rolando
Chagoya de Sánchez, Victoria
Martínez-Pérez, Lidia
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Introduction.
Cirrhosis is a chronic degenerative illness characterized by changes in normal liver architecture, failure of hepatic function, and impairment of proliferative activity.
The aim of this study is to know how IFC-305 compound induces proliferation of the liver during reversion of cirrhosis.
Methods.
Once cirrhosis has been installed by CCl4 treatment for 10 weeks in male Wistar rats, they were divided into four groups: two received saline and two received the compound; all were euthanized at 5 and 10 weeks of treatment.
Liver homogenate, mitochondria, and nucleus were used to measure cyclins, CDKs, and cell cycle regulatory proteins PCNA, pRb, p53, E2F, p21, p27, HGF, liver ATP, and mitochondrial function.
Results.
Diminution and small changes were observed in the studied proteins in the cirrhotic animals without treatment.
The IFC-305-treated rats showed a clear increase in most of the proteins studied mainly in PCNA and CDK6, and a marked increased in ATP and mitochondrial function.
Discussion/Conclusion.
IFC-305 induces a recovery of the cell cycle inhibition promoting recovery of DNA damage through the action of PCNA and p53.
The increase in energy and preservation of mitochondrial function contribute to recovering the proliferative function.
American Psychological Association (APA)
Chagoya de Sánchez, Victoria& Martínez-Pérez, Lidia& Hernández-Muñoz, Rolando& Velasco-Loyden, Gabriela. 2012. Recovery of the Cell Cycle Inhibition in CCl4-Induced Cirrhosis by the Adenosine Derivative IFC-305. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-454937
Modern Language Association (MLA)
Chagoya de Sánchez, Victoria…[et al.]. Recovery of the Cell Cycle Inhibition in CCl4-Induced Cirrhosis by the Adenosine Derivative IFC-305. International Journal of Hepatology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-454937
American Medical Association (AMA)
Chagoya de Sánchez, Victoria& Martínez-Pérez, Lidia& Hernández-Muñoz, Rolando& Velasco-Loyden, Gabriela. Recovery of the Cell Cycle Inhibition in CCl4-Induced Cirrhosis by the Adenosine Derivative IFC-305. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-454937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454937