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Effects of Salvianolic Acid B on Protein Expression in Human Umbilical Vein Endothelial Cells
المؤلفون المشاركون
Wang, Hui-Lin
Chang, Tsong-Min
Shi, Guey-Yueh
Su, Yan-Di
Wen, Hsin-Yun
Wu, Chieh-Hsi
Wu, Hua-Lin
Huang, Huey-Chun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Salvianolic acid B (Sal B), a pure water-soluble compound extracted from Radix Salviae miltiorrhizae, has been reported to possess potential cardioprotective efficacy.
To identify proteins or pathways by which Sal B might exert its protective activities on the cardiovascular system, two-dimensional gel electrophoresis-based comparative proteomics was performed, and proteins altered in their expression level after Sal B treatment were identified by MALDI-TOF MS/MS.
Human umbilical vein endothelial cells (HUVECs) were incubated at Sal B concentrations that can be reached in human plasma by pharmacological intervention.
Results indicated that caldesmon, an actin-stabilizing protein, was downregulated in Sal B-exposed HUVECs.
Proteins that showed increased expression levels upon Sal B treatment were vimentin, T-complex protein 1, protein disulfide isomerase, tropomyosin alpha, heat shock protein beta-1, UBX domain-containing protein 1, alpha enolase, and peroxiredoxin-2.
Additionally, Sal B leads to increased phosphorylation of nucleophosmin in a dose-dependent manner and promotes proliferation of HUVECs.
We found that Sal B exhibited a coordinated regulation of enzymes and proteins involved in cytoskeletal reorganization, oxidative stress, and cell growth.
Our investigation would provide understanding to the endothelium protection information of Sal B.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Tsong-Min& Shi, Guey-Yueh& Wu, Hua-Lin& Wu, Chieh-Hsi& Su, Yan-Di& Wang, Hui-Lin…[et al.]. 2011. Effects of Salvianolic Acid B on Protein Expression in Human Umbilical Vein Endothelial Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-454979
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Tsong-Min…[et al.]. Effects of Salvianolic Acid B on Protein Expression in Human Umbilical Vein Endothelial Cells. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-454979
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Tsong-Min& Shi, Guey-Yueh& Wu, Hua-Lin& Wu, Chieh-Hsi& Su, Yan-Di& Wang, Hui-Lin…[et al.]. Effects of Salvianolic Acid B on Protein Expression in Human Umbilical Vein Endothelial Cells. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-454979
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454979
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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