Urine Glycoprotein Profile Reveals Novel Markers for Chronic Kidney Disease
المؤلفون المشاركون
Pennathur, Subramaniam
Slocum, Jessica L.
Vivekanandan-Giri, Anuradha
Lubman, David M.
Buller, Carolyn L.
Basrur, Venkatesha
Kretzler, Matthias
Pop-Busui, Rodica
Ju, Wenjun
المصدر
International Journal of Proteomics
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-10-10
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Chronic kidney disease (CKD) is a significant public health problem, and progression to end-stage renal disease leads to dramatic increases in morbidity and mortality.
The mechanisms underlying progression of disease are poorly defined, and current noninvasive markers incompletely correlate with disease progression.
Therefore, there is a great need for discovering novel markers for CKD.
We utilized a glycoproteomic profiling approach to test the hypothesis that the urinary glycoproteome profile from subjects with CKD would be distinct from healthy controls.
N-linked glycoproteins were isolated and enriched from the urine of healthy controls and subjects with CKD.
This strategy identified several differentially expressed proteins in CKD, including a diverse array of proteins with endopeptidase inhibitor activity, protein binding functions, and acute-phase/immune-stress response activity supporting the proposal that inflammation may play a central role in CKD.
Additionally, several of these proteins have been previously linked to kidney disease implicating a mechanistic role in disease pathogenesis.
Collectively, our observations suggest that the human urinary glycoproteome may serve as a discovery source for novel mechanism-based biomarkers of CKD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vivekanandan-Giri, Anuradha& Slocum, Jessica L.& Buller, Carolyn L.& Basrur, Venkatesha& Ju, Wenjun& Pop-Busui, Rodica…[et al.]. 2011. Urine Glycoprotein Profile Reveals Novel Markers for Chronic Kidney Disease. International Journal of Proteomics،Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-455138
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vivekanandan-Giri, Anuradha…[et al.]. Urine Glycoprotein Profile Reveals Novel Markers for Chronic Kidney Disease. International Journal of Proteomics No. 2011 (2011), pp.1-18.
https://search.emarefa.net/detail/BIM-455138
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vivekanandan-Giri, Anuradha& Slocum, Jessica L.& Buller, Carolyn L.& Basrur, Venkatesha& Ju, Wenjun& Pop-Busui, Rodica…[et al.]. Urine Glycoprotein Profile Reveals Novel Markers for Chronic Kidney Disease. International Journal of Proteomics. 2011. Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-455138
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-455138
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر