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Urine Glycoprotein Profile Reveals Novel Markers for Chronic Kidney Disease
Joint Authors
Pennathur, Subramaniam
Slocum, Jessica L.
Vivekanandan-Giri, Anuradha
Lubman, David M.
Buller, Carolyn L.
Basrur, Venkatesha
Kretzler, Matthias
Pop-Busui, Rodica
Ju, Wenjun
Source
International Journal of Proteomics
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-10
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Chronic kidney disease (CKD) is a significant public health problem, and progression to end-stage renal disease leads to dramatic increases in morbidity and mortality.
The mechanisms underlying progression of disease are poorly defined, and current noninvasive markers incompletely correlate with disease progression.
Therefore, there is a great need for discovering novel markers for CKD.
We utilized a glycoproteomic profiling approach to test the hypothesis that the urinary glycoproteome profile from subjects with CKD would be distinct from healthy controls.
N-linked glycoproteins were isolated and enriched from the urine of healthy controls and subjects with CKD.
This strategy identified several differentially expressed proteins in CKD, including a diverse array of proteins with endopeptidase inhibitor activity, protein binding functions, and acute-phase/immune-stress response activity supporting the proposal that inflammation may play a central role in CKD.
Additionally, several of these proteins have been previously linked to kidney disease implicating a mechanistic role in disease pathogenesis.
Collectively, our observations suggest that the human urinary glycoproteome may serve as a discovery source for novel mechanism-based biomarkers of CKD.
American Psychological Association (APA)
Vivekanandan-Giri, Anuradha& Slocum, Jessica L.& Buller, Carolyn L.& Basrur, Venkatesha& Ju, Wenjun& Pop-Busui, Rodica…[et al.]. 2011. Urine Glycoprotein Profile Reveals Novel Markers for Chronic Kidney Disease. International Journal of Proteomics،Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-455138
Modern Language Association (MLA)
Vivekanandan-Giri, Anuradha…[et al.]. Urine Glycoprotein Profile Reveals Novel Markers for Chronic Kidney Disease. International Journal of Proteomics No. 2011 (2011), pp.1-18.
https://search.emarefa.net/detail/BIM-455138
American Medical Association (AMA)
Vivekanandan-Giri, Anuradha& Slocum, Jessica L.& Buller, Carolyn L.& Basrur, Venkatesha& Ju, Wenjun& Pop-Busui, Rodica…[et al.]. Urine Glycoprotein Profile Reveals Novel Markers for Chronic Kidney Disease. International Journal of Proteomics. 2011. Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-455138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455138