Dioxaphosphorinane-Constrained Nucleic Acid Dinucleotides as Tools for Structural Tuning of Nucleic Acids

المؤلفون المشاركون

Payrastre, Corinne
Catana, Dan-Andrei
Maturano, Marie
Tarrat, Nathalie
Escudier, Jean-Marc
Renard, Brice-Loïc

المصدر

Journal of Nucleic Acids

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-17، 17ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-10-24

دولة النشر

مصر

عدد الصفحات

17

التخصصات الرئيسية

الأحياء
الطب البشري

الملخص EN

We describe a rational approach devoted to modulate the sugar-phosphate backbone geometry of nucleic acids.

Constraints were generated by connecting one oxygen of the phosphate group to a carbon of the sugar moiety.

The so-called dioxaphosphorinane rings were introduced at key positions along the sugar-phosphate backbone allowing the control of the six-torsion angles α to ζ defining the polymer structure.

The syntheses of all the members of the D-CNA family are described, and we emphasize the effect on secondary structure stabilization of a couple of diastereoisomers of α,β-D-CNA exhibiting wether B-type canonical values or not.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Catana, Dan-Andrei& Renard, Brice-Loïc& Maturano, Marie& Payrastre, Corinne& Tarrat, Nathalie& Escudier, Jean-Marc. 2012. Dioxaphosphorinane-Constrained Nucleic Acid Dinucleotides as Tools for Structural Tuning of Nucleic Acids. Journal of Nucleic Acids،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-455254

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Catana, Dan-Andrei…[et al.]. Dioxaphosphorinane-Constrained Nucleic Acid Dinucleotides as Tools for Structural Tuning of Nucleic Acids. Journal of Nucleic Acids No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-455254

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Catana, Dan-Andrei& Renard, Brice-Loïc& Maturano, Marie& Payrastre, Corinne& Tarrat, Nathalie& Escudier, Jean-Marc. Dioxaphosphorinane-Constrained Nucleic Acid Dinucleotides as Tools for Structural Tuning of Nucleic Acids. Journal of Nucleic Acids. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-455254

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-455254