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Dioxaphosphorinane-Constrained Nucleic Acid Dinucleotides as Tools for Structural Tuning of Nucleic Acids
Joint Authors
Payrastre, Corinne
Catana, Dan-Andrei
Maturano, Marie
Tarrat, Nathalie
Escudier, Jean-Marc
Renard, Brice-Loïc
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-24
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
We describe a rational approach devoted to modulate the sugar-phosphate backbone geometry of nucleic acids.
Constraints were generated by connecting one oxygen of the phosphate group to a carbon of the sugar moiety.
The so-called dioxaphosphorinane rings were introduced at key positions along the sugar-phosphate backbone allowing the control of the six-torsion angles α to ζ defining the polymer structure.
The syntheses of all the members of the D-CNA family are described, and we emphasize the effect on secondary structure stabilization of a couple of diastereoisomers of α,β-D-CNA exhibiting wether B-type canonical values or not.
American Psychological Association (APA)
Catana, Dan-Andrei& Renard, Brice-Loïc& Maturano, Marie& Payrastre, Corinne& Tarrat, Nathalie& Escudier, Jean-Marc. 2012. Dioxaphosphorinane-Constrained Nucleic Acid Dinucleotides as Tools for Structural Tuning of Nucleic Acids. Journal of Nucleic Acids،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-455254
Modern Language Association (MLA)
Catana, Dan-Andrei…[et al.]. Dioxaphosphorinane-Constrained Nucleic Acid Dinucleotides as Tools for Structural Tuning of Nucleic Acids. Journal of Nucleic Acids No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-455254
American Medical Association (AMA)
Catana, Dan-Andrei& Renard, Brice-Loïc& Maturano, Marie& Payrastre, Corinne& Tarrat, Nathalie& Escudier, Jean-Marc. Dioxaphosphorinane-Constrained Nucleic Acid Dinucleotides as Tools for Structural Tuning of Nucleic Acids. Journal of Nucleic Acids. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-455254
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455254