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RSC96 Schwann Cell Proliferation and Survival Induced by Dilong through PI3KAkt Signaling Mediated by IGF-I
المؤلفون المشاركون
Shih, Ying-Ting
Chang, Yung-Ming
Huang, Chih-Yang
Shu, Wen-Tong
Lai, Tung-Yuan
Tsai, Fuu-Jen
Chen, Yueh-Sheng
Kuo, Wei-Wen
Tsai, Chang-Hai
Chen, Ying-Yu
Kuo, Wu-Hsien
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Schwann cell proliferation is critical for the regeneration of injured nerves.
Dilongs are widely used in Chinese herbal medicine to remove stasis and stimulate wound-healing functions.
Exactly how this Chinese herbal medicine promotes tissue survival remains unclear.
The aim of the present study was to investigate the molecular mechanisms by which Dilong promote neuron regeneration.
Our results show that treatment with extract of Dilong induces the phosphorylation of the insulin-like growth factor-I (IGF-I)-mediated phosphatidylinositol 3-kinase/serine-threonine kinase (PI3K/Akt) pathway, and activates protein expression of cell nuclear antigen (PCNA) in a time-dependent manner.
Cell cycle analysis showed that G1 transits into the S phase in 12–16 h, and S transits into the G2 phase 20 h after exposure to earthworm extract.
Strong expression of cyclin D1, cyclin E and cyclin A occurs in a time-dependent manner.
Small interfering RNA (siRNA)-mediated knockdown of PI3K significantly reduced PI3K protein expression levels, resulting in Bcl2 survival factor reduction and a marked blockage of G1 to S transition in proliferating cells.
These results demonstrate that Dilong promotes the proliferation and survival of RSC96 cells via IGF-I signaling.
The mechanism is mainly dependent on the PI3K protein.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Yung-Ming& Kuo, Wu-Hsien& Lai, Tung-Yuan& Shih, Ying-Ting& Tsai, Fuu-Jen& Tsai, Chang-Hai…[et al.]. 2011. RSC96 Schwann Cell Proliferation and Survival Induced by Dilong through PI3KAkt Signaling Mediated by IGF-I. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-455277
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Yung-Ming…[et al.]. RSC96 Schwann Cell Proliferation and Survival Induced by Dilong through PI3KAkt Signaling Mediated by IGF-I. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-455277
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Yung-Ming& Kuo, Wu-Hsien& Lai, Tung-Yuan& Shih, Ying-Ting& Tsai, Fuu-Jen& Tsai, Chang-Hai…[et al.]. RSC96 Schwann Cell Proliferation and Survival Induced by Dilong through PI3KAkt Signaling Mediated by IGF-I. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-455277
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-455277
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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