Delivery of Exogenous Antigens to Induce Cytotoxic CD8+ T Lymphocyte Responses

الملخص EN

Vaccines intended to induce a cytotoxic CD8+ T-cell response are highly sought after.

However, some of these vaccines can be problematic if they replicate in the host.

An alternative strategy is to exploit cross-presentation of exogenous antigens to express peptides on major histocompatibility complex (MHC) class I molecules.

During cross-presentation, the delivered exogenous antigen can be taken up and processed through diverse mechanisms.

Here, we will discuss the recent advances regarding the complex nature of the cross-priming process and the models that reflect its relevance in vivo.

Moreover, we summarize current data that explore potential adjuvants and vaccine vectors that deliver antigens to activate CD8+ T cells relying on cross-presentation.