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Delivery of Exogenous Antigens to Induce Cytotoxic CD8+ T Lymphocyte Responses
Joint Authors
Gambhir, Vandana
Kim, Julia
Alatery, Attiya
Basta, Sameh
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Vaccines intended to induce a cytotoxic CD8+ T-cell response are highly sought after.
However, some of these vaccines can be problematic if they replicate in the host.
An alternative strategy is to exploit cross-presentation of exogenous antigens to express peptides on major histocompatibility complex (MHC) class I molecules.
During cross-presentation, the delivered exogenous antigen can be taken up and processed through diverse mechanisms.
Here, we will discuss the recent advances regarding the complex nature of the cross-priming process and the models that reflect its relevance in vivo.
Moreover, we summarize current data that explore potential adjuvants and vaccine vectors that deliver antigens to activate CD8+ T cells relying on cross-presentation.
American Psychological Association (APA)
Kim, Julia& Gambhir, Vandana& Alatery, Attiya& Basta, Sameh. 2010. Delivery of Exogenous Antigens to Induce Cytotoxic CD8+ T Lymphocyte Responses. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-455532
Modern Language Association (MLA)
Kim, Julia…[et al.]. Delivery of Exogenous Antigens to Induce Cytotoxic CD8+ T Lymphocyte Responses. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-455532
American Medical Association (AMA)
Kim, Julia& Gambhir, Vandana& Alatery, Attiya& Basta, Sameh. Delivery of Exogenous Antigens to Induce Cytotoxic CD8+ T Lymphocyte Responses. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-455532
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455532