Trends in Decline of Antiretroviral Resistance among ARV-Experienced Patients in the HIV Outpatient Study : 1999–2008
المؤلفون المشاركون
Brooks, John T.
Palella, Frank J.
Young, Benjamin
Buchacz, Kate
Novak, Richard M.
Chmiel, Joan S.
Baker, Rose K.
Ward, Douglas J.
Yangco, Bienvenido G.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Little is known about temporal trends in frequencies of clinically relevant ARV resistance mutations in HIV strains from U.S.
patients undergoing genotypic testing (GT) in routine HIV care.
Methods.
We analyzed cumulative frequency of HIV resistance among patients in the HIV Outpatient Study (HOPS) who, during 1999–2008 and while prescribed antiretrovirals, underwent GT with plasma HIV RNA >1,000 copies/mL.
Exposure ≥4 months to each of three major antiretroviral classes (NRTI, NNRTI and PI) was defined as triple-class exposure (TCE).
Results.
906 patients contributed 1,570 GT results.
The annual frequency of any major resistance mutations decreased during 1999–2008 (88% to 79%, P=0.05).
Resistance to PIs decreased among PI-exposed patients (71% to 46%, P=0.010) as exposure to ritonavir-boosted PIs increased (6% to 81%, P<0.001).
Non-significant declines were observed in resistance to NRTIs among NRTI-exposed (82% to 67%), and triple-class-resistance among TCE patients (66% to 41%), but not to NNRTIs among NNRTI-exposed.
Conclusions.
HIV resistance was common but declined in HIV isolates from subgroups of ARV-experienced HOPS patients during 1999–2008.
Resistance to PIs among PI-exposed patients decreased, possibly due to increased representation of patients whose only PI exposures were to boosted PIs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Buchacz, Kate& Baker, Rose K.& Ward, Douglas J.& Palella, Frank J.& Chmiel, Joan S.& Young, Benjamin…[et al.]. 2012. Trends in Decline of Antiretroviral Resistance among ARV-Experienced Patients in the HIV Outpatient Study : 1999–2008. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-455669
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Buchacz, Kate…[et al.]. Trends in Decline of Antiretroviral Resistance among ARV-Experienced Patients in the HIV Outpatient Study : 1999–2008. AIDS Research and Treatment No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-455669
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Buchacz, Kate& Baker, Rose K.& Ward, Douglas J.& Palella, Frank J.& Chmiel, Joan S.& Young, Benjamin…[et al.]. Trends in Decline of Antiretroviral Resistance among ARV-Experienced Patients in the HIV Outpatient Study : 1999–2008. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-455669
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-455669
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر