Trends in Decline of Antiretroviral Resistance among ARV-Experienced Patients in the HIV Outpatient Study : 1999–2008
Joint Authors
Brooks, John T.
Palella, Frank J.
Young, Benjamin
Buchacz, Kate
Novak, Richard M.
Chmiel, Joan S.
Baker, Rose K.
Ward, Douglas J.
Yangco, Bienvenido G.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Little is known about temporal trends in frequencies of clinically relevant ARV resistance mutations in HIV strains from U.S.
patients undergoing genotypic testing (GT) in routine HIV care.
Methods.
We analyzed cumulative frequency of HIV resistance among patients in the HIV Outpatient Study (HOPS) who, during 1999–2008 and while prescribed antiretrovirals, underwent GT with plasma HIV RNA >1,000 copies/mL.
Exposure ≥4 months to each of three major antiretroviral classes (NRTI, NNRTI and PI) was defined as triple-class exposure (TCE).
Results.
906 patients contributed 1,570 GT results.
The annual frequency of any major resistance mutations decreased during 1999–2008 (88% to 79%, P=0.05).
Resistance to PIs decreased among PI-exposed patients (71% to 46%, P=0.010) as exposure to ritonavir-boosted PIs increased (6% to 81%, P<0.001).
Non-significant declines were observed in resistance to NRTIs among NRTI-exposed (82% to 67%), and triple-class-resistance among TCE patients (66% to 41%), but not to NNRTIs among NNRTI-exposed.
Conclusions.
HIV resistance was common but declined in HIV isolates from subgroups of ARV-experienced HOPS patients during 1999–2008.
Resistance to PIs among PI-exposed patients decreased, possibly due to increased representation of patients whose only PI exposures were to boosted PIs.
American Psychological Association (APA)
Buchacz, Kate& Baker, Rose K.& Ward, Douglas J.& Palella, Frank J.& Chmiel, Joan S.& Young, Benjamin…[et al.]. 2012. Trends in Decline of Antiretroviral Resistance among ARV-Experienced Patients in the HIV Outpatient Study : 1999–2008. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-455669
Modern Language Association (MLA)
Buchacz, Kate…[et al.]. Trends in Decline of Antiretroviral Resistance among ARV-Experienced Patients in the HIV Outpatient Study : 1999–2008. AIDS Research and Treatment No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-455669
American Medical Association (AMA)
Buchacz, Kate& Baker, Rose K.& Ward, Douglas J.& Palella, Frank J.& Chmiel, Joan S.& Young, Benjamin…[et al.]. Trends in Decline of Antiretroviral Resistance among ARV-Experienced Patients in the HIV Outpatient Study : 1999–2008. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-455669
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455669