Concurrent Dual Contrast for Cellular Magnetic Resonance Imaging Using Gadolinium Oxide and Iron Oxide Nanoparticles
المؤلفون المشاركون
Loai, Yasir
Ganesh, Tameshwar
Margaret Cheng, Hai-Ling
المصدر
International Journal of Molecular Imaging
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Rationale and Objectives.
Concurrent visualization of differential targets in cellular and molecular imaging is valuable for resolving processes spatially and temporally, as in monitoring different cell subtypes.
The purpose of this study was to demonstrate concurrent, dual (positive and negative) contrast visualization on magnetic resonance imaging (MRI) of two colocalized cell populations labeled with Gadolinium “Gd” oxide and iron “Fe” oxide nanoparticles.
Materials and Methods.
Human aortic endothelial cells (EC) and smooth muscle cells (SMC) were labeled with various concentrations of Gd oxide and Fe oxide, respectively.
MRI on single- or mixed-cell samples was performed at 7 tesla.
Proper cell phenotype expressions, cell uptake of contrast agents, and the effect of labeling on cell viability and proliferation were also determined.
Results.
Both contrast agents were efficiently taken up by cells, with viability and proliferation largely unaffected.
On MRI, the positive contrast associated with Gd oxide-labeled EC and negative contrast associated with Fe oxide-labeled SMC discriminated the presence of each cell type, whether it existed alone or colocalized in a mixed-cell sample.
Conclusion.
It is feasible to use Gd oxide and Fe oxide for dual contrast and concurrent discrimination of two colocalized cell populations on MRI at 7 tesla.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Loai, Yasir& Ganesh, Tameshwar& Margaret Cheng, Hai-Ling. 2012. Concurrent Dual Contrast for Cellular Magnetic Resonance Imaging Using Gadolinium Oxide and Iron Oxide Nanoparticles. International Journal of Molecular Imaging،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-455749
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Loai, Yasir…[et al.]. Concurrent Dual Contrast for Cellular Magnetic Resonance Imaging Using Gadolinium Oxide and Iron Oxide Nanoparticles. International Journal of Molecular Imaging No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-455749
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Loai, Yasir& Ganesh, Tameshwar& Margaret Cheng, Hai-Ling. Concurrent Dual Contrast for Cellular Magnetic Resonance Imaging Using Gadolinium Oxide and Iron Oxide Nanoparticles. International Journal of Molecular Imaging. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-455749
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-455749
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر