Antioxidant and Protective Effect of Ethyl Acetate Extract of Podophyllum hexandrum Rhizome on Carbon Tetrachloride Induced Rat Liver Injury
المؤلفون المشاركون
Haq, Ehtishamul
Masood, Akbar
Ganie, Showkat Ahmad
Hamid, Abid
Zargar, Mohmmad Afzal
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-09
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The antioxidant and hepatoprotective activities of ethyl acetate extract was carefully investigated by the methods of DPPH radical scavenging activity, Hydroxyl radical scavenging activity, superoxide radical scavenging activity, hydrogen peroxide radical scavenging activity, and its reducing power ability.
All these in vitro antioxidant activities were concentration dependent, which were compared with standard antioxidants such as BHT, α-tocopherol.
The hepatoprotective potential of Podophyllum hexandrum extract was also evaluated in male Wistar rats against carbon tetrachloride- (CCl4-) induced liver damage.
Pretreated rats were given ethyl acetate extract at 20, 30, and 50 mg/kg dose prior to CCl4 administration (1 mL/kg, 1:1 in olive oil).
Rats pretreated with P.
hexandrum extract remarkably prevented the elevation of serum AST, ALT, LDH, and liver lipid peroxides in CCl4-treated rats.
Hepatic glutathione levels were significantly increased by the treatment with the extract in all the experimental groups.
The extract at the tested doses also restored the levels of liver homogenate enzymes (glutathione peroxidase, glutathione reductase, superoxide dismutase, and glutathione-S-transferase) significantly.
This study suggests that ethyl acetate extract of P.
hexandrum has a liver-protective effect against CCl4-induced hepatotoxicity and possess in vitro antioxidant activities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ganie, Showkat Ahmad& Haq, Ehtishamul& Masood, Akbar& Hamid, Abid& Zargar, Mohmmad Afzal. 2011. Antioxidant and Protective Effect of Ethyl Acetate Extract of Podophyllum hexandrum Rhizome on Carbon Tetrachloride Induced Rat Liver Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-456300
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ganie, Showkat Ahmad…[et al.]. Antioxidant and Protective Effect of Ethyl Acetate Extract of Podophyllum hexandrum Rhizome on Carbon Tetrachloride Induced Rat Liver Injury. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-456300
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ganie, Showkat Ahmad& Haq, Ehtishamul& Masood, Akbar& Hamid, Abid& Zargar, Mohmmad Afzal. Antioxidant and Protective Effect of Ethyl Acetate Extract of Podophyllum hexandrum Rhizome on Carbon Tetrachloride Induced Rat Liver Injury. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-456300
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456300
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر