Antioxidant and Protective Effect of Ethyl Acetate Extract of Podophyllum hexandrum Rhizome on Carbon Tetrachloride Induced Rat Liver Injury
Joint Authors
Haq, Ehtishamul
Masood, Akbar
Ganie, Showkat Ahmad
Hamid, Abid
Zargar, Mohmmad Afzal
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The antioxidant and hepatoprotective activities of ethyl acetate extract was carefully investigated by the methods of DPPH radical scavenging activity, Hydroxyl radical scavenging activity, superoxide radical scavenging activity, hydrogen peroxide radical scavenging activity, and its reducing power ability.
All these in vitro antioxidant activities were concentration dependent, which were compared with standard antioxidants such as BHT, α-tocopherol.
The hepatoprotective potential of Podophyllum hexandrum extract was also evaluated in male Wistar rats against carbon tetrachloride- (CCl4-) induced liver damage.
Pretreated rats were given ethyl acetate extract at 20, 30, and 50 mg/kg dose prior to CCl4 administration (1 mL/kg, 1:1 in olive oil).
Rats pretreated with P.
hexandrum extract remarkably prevented the elevation of serum AST, ALT, LDH, and liver lipid peroxides in CCl4-treated rats.
Hepatic glutathione levels were significantly increased by the treatment with the extract in all the experimental groups.
The extract at the tested doses also restored the levels of liver homogenate enzymes (glutathione peroxidase, glutathione reductase, superoxide dismutase, and glutathione-S-transferase) significantly.
This study suggests that ethyl acetate extract of P.
hexandrum has a liver-protective effect against CCl4-induced hepatotoxicity and possess in vitro antioxidant activities.
American Psychological Association (APA)
Ganie, Showkat Ahmad& Haq, Ehtishamul& Masood, Akbar& Hamid, Abid& Zargar, Mohmmad Afzal. 2011. Antioxidant and Protective Effect of Ethyl Acetate Extract of Podophyllum hexandrum Rhizome on Carbon Tetrachloride Induced Rat Liver Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-456300
Modern Language Association (MLA)
Ganie, Showkat Ahmad…[et al.]. Antioxidant and Protective Effect of Ethyl Acetate Extract of Podophyllum hexandrum Rhizome on Carbon Tetrachloride Induced Rat Liver Injury. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-456300
American Medical Association (AMA)
Ganie, Showkat Ahmad& Haq, Ehtishamul& Masood, Akbar& Hamid, Abid& Zargar, Mohmmad Afzal. Antioxidant and Protective Effect of Ethyl Acetate Extract of Podophyllum hexandrum Rhizome on Carbon Tetrachloride Induced Rat Liver Injury. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-456300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456300