Polymorphisms of MTHFR Associated with Higher RelapseDeath Ratio and Delayed Weekly MTX Administration in Pediatric Lymphoid Malignancies
المؤلفون المشاركون
Tsuchida, Masahiro
Iwabuchi, Atsushi
Saito, Makoto
Nakajima-Yamaguchi, Ryoko
Fukushima, Hiroko
Suzuki, Ryoko
Kiyokawa, Nobutaka
Kobayashi, Chie
Fukushima, Takashi
Kato, Keisuke
Noguchi, Emiko
Yoshimi, Ai
Sumazaki, Ryo
Sakai, Aiko
Koike, Kazutoshi
Takahashi, Hideto
Nakao, Tomohei
المصدر
Leukemia Research and Treatment
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Backgrounds.
Outcome of childhood malignancy has been improved mostly due to the advances in diagnostic techniques and treatment strategies.
While methotrexate (MTX) related polymorphisms have been under investigation in childhood malignancies, many controversial results have been offered.
Objectives.
To evaluate associations of polymorphisms related MTX metabolisms and clinical course in childhood lymphoid malignancies.
Method.
Eighty-two acute lymphoblastic leukemia and 21 non-Hodgkin’s lymphoma children were enrolled in this study.
Four single nucleotide polymorphisms in 2 genes (MTHFR (rs1801133/c.677C>T/p.Ala222Val and rs1801131/c.1298A>C/p.Glu429Ala) and SLCO1B1 (rs4149056/c.521T>C/p.V174A and rs11045879/c.1865+4846T>C)) were genotyped by Taqman PCR method or direct sequencing.
Clinical courses were reviewed retrospectively.
Results.
No patient who had the AC/CC genotype of rs1801131 (MTHFR) had relapsed or died, in which distribution was statistically different among the AA genotype of rs1801131 (P=0.004).
Polymorphisms of SLCO1B1 (rs11045879 and rs4149056) were not correlated with MTX concentrations, adverse events, or disease outcome.
Conclusions.
Polymorphisms of MTHFR (rs1801131) could be the plausive candidate for prognostic predictor in childhood lymphoid malignancies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fukushima, Hiroko& Fukushima, Takashi& Sakai, Aiko& Suzuki, Ryoko& Nakajima-Yamaguchi, Ryoko& Kobayashi, Chie…[et al.]. 2013. Polymorphisms of MTHFR Associated with Higher RelapseDeath Ratio and Delayed Weekly MTX Administration in Pediatric Lymphoid Malignancies. Leukemia Research and Treatment،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-456356
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fukushima, Hiroko…[et al.]. Polymorphisms of MTHFR Associated with Higher RelapseDeath Ratio and Delayed Weekly MTX Administration in Pediatric Lymphoid Malignancies. Leukemia Research and Treatment No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-456356
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fukushima, Hiroko& Fukushima, Takashi& Sakai, Aiko& Suzuki, Ryoko& Nakajima-Yamaguchi, Ryoko& Kobayashi, Chie…[et al.]. Polymorphisms of MTHFR Associated with Higher RelapseDeath Ratio and Delayed Weekly MTX Administration in Pediatric Lymphoid Malignancies. Leukemia Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-456356
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456356
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر