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Polymorphisms of MTHFR Associated with Higher RelapseDeath Ratio and Delayed Weekly MTX Administration in Pediatric Lymphoid Malignancies
Joint Authors
Tsuchida, Masahiro
Iwabuchi, Atsushi
Saito, Makoto
Nakajima-Yamaguchi, Ryoko
Fukushima, Hiroko
Suzuki, Ryoko
Kiyokawa, Nobutaka
Kobayashi, Chie
Fukushima, Takashi
Kato, Keisuke
Noguchi, Emiko
Yoshimi, Ai
Sumazaki, Ryo
Sakai, Aiko
Koike, Kazutoshi
Takahashi, Hideto
Nakao, Tomohei
Source
Leukemia Research and Treatment
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
Backgrounds.
Outcome of childhood malignancy has been improved mostly due to the advances in diagnostic techniques and treatment strategies.
While methotrexate (MTX) related polymorphisms have been under investigation in childhood malignancies, many controversial results have been offered.
Objectives.
To evaluate associations of polymorphisms related MTX metabolisms and clinical course in childhood lymphoid malignancies.
Method.
Eighty-two acute lymphoblastic leukemia and 21 non-Hodgkin’s lymphoma children were enrolled in this study.
Four single nucleotide polymorphisms in 2 genes (MTHFR (rs1801133/c.677C>T/p.Ala222Val and rs1801131/c.1298A>C/p.Glu429Ala) and SLCO1B1 (rs4149056/c.521T>C/p.V174A and rs11045879/c.1865+4846T>C)) were genotyped by Taqman PCR method or direct sequencing.
Clinical courses were reviewed retrospectively.
Results.
No patient who had the AC/CC genotype of rs1801131 (MTHFR) had relapsed or died, in which distribution was statistically different among the AA genotype of rs1801131 (P=0.004).
Polymorphisms of SLCO1B1 (rs11045879 and rs4149056) were not correlated with MTX concentrations, adverse events, or disease outcome.
Conclusions.
Polymorphisms of MTHFR (rs1801131) could be the plausive candidate for prognostic predictor in childhood lymphoid malignancies.
American Psychological Association (APA)
Fukushima, Hiroko& Fukushima, Takashi& Sakai, Aiko& Suzuki, Ryoko& Nakajima-Yamaguchi, Ryoko& Kobayashi, Chie…[et al.]. 2013. Polymorphisms of MTHFR Associated with Higher RelapseDeath Ratio and Delayed Weekly MTX Administration in Pediatric Lymphoid Malignancies. Leukemia Research and Treatment،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-456356
Modern Language Association (MLA)
Fukushima, Hiroko…[et al.]. Polymorphisms of MTHFR Associated with Higher RelapseDeath Ratio and Delayed Weekly MTX Administration in Pediatric Lymphoid Malignancies. Leukemia Research and Treatment No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-456356
American Medical Association (AMA)
Fukushima, Hiroko& Fukushima, Takashi& Sakai, Aiko& Suzuki, Ryoko& Nakajima-Yamaguchi, Ryoko& Kobayashi, Chie…[et al.]. Polymorphisms of MTHFR Associated with Higher RelapseDeath Ratio and Delayed Weekly MTX Administration in Pediatric Lymphoid Malignancies. Leukemia Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-456356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456356