Excitation-Contraction Coupling between Human Atrial Myocytes with Fibroblasts and Stretch Activated Channel Current : A Simulation Study

المؤلفون المشاركون

Xia, Ling
Zhan, Heqing

المصدر

Computational and Mathematical Methods in Medicine

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-08-13

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Myocytes have been regarded as the main objectives in most cardiac modeling studies and attracted a lot of attention.

Connective tissue cells, such as fibroblasts (Fbs), also play crucial role in cardiac function.

This study proposed an integrated myocyte-Isac-Fb electromechanical model to investigate the effect of Fbs and stretch activated ion channel current (Isac) on cardiac electrical excitation conduction and mechanical contraction.

At the cellular level, an active Fb model was coupled with a human atrial myocyte electrophysiological model (including Isac) and a mechanical model.

At the tissue level, electrical excitation conduction was coupled with an elastic mechanical model, in which finite difference method (FDM) was used to solve the electrical excitation equations, while finite element method (FEM) was used for the mechanics equations.

The simulation results showed that Fbs and Isac coupling caused diverse effects on action potential morphology during repolarization, depolarized the resting membrane potential of the human atrial myocyte, slowed down wave propagation, and decreased strains in fibrotic tissue.

This preliminary simulation study indicates that Fbs and Isac have important implications for modulating cardiac electromechanical behavior and should be considered in future cardiac modeling studies.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhan, Heqing& Xia, Ling. 2013. Excitation-Contraction Coupling between Human Atrial Myocytes with Fibroblasts and Stretch Activated Channel Current : A Simulation Study. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-456379

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhan, Heqing& Xia, Ling. Excitation-Contraction Coupling between Human Atrial Myocytes with Fibroblasts and Stretch Activated Channel Current : A Simulation Study. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-456379

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhan, Heqing& Xia, Ling. Excitation-Contraction Coupling between Human Atrial Myocytes with Fibroblasts and Stretch Activated Channel Current : A Simulation Study. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-456379

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-456379