Excitation-Contraction Coupling between Human Atrial Myocytes with Fibroblasts and Stretch Activated Channel Current : A Simulation Study
Joint Authors
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Myocytes have been regarded as the main objectives in most cardiac modeling studies and attracted a lot of attention.
Connective tissue cells, such as fibroblasts (Fbs), also play crucial role in cardiac function.
This study proposed an integrated myocyte-Isac-Fb electromechanical model to investigate the effect of Fbs and stretch activated ion channel current (Isac) on cardiac electrical excitation conduction and mechanical contraction.
At the cellular level, an active Fb model was coupled with a human atrial myocyte electrophysiological model (including Isac) and a mechanical model.
At the tissue level, electrical excitation conduction was coupled with an elastic mechanical model, in which finite difference method (FDM) was used to solve the electrical excitation equations, while finite element method (FEM) was used for the mechanics equations.
The simulation results showed that Fbs and Isac coupling caused diverse effects on action potential morphology during repolarization, depolarized the resting membrane potential of the human atrial myocyte, slowed down wave propagation, and decreased strains in fibrotic tissue.
This preliminary simulation study indicates that Fbs and Isac have important implications for modulating cardiac electromechanical behavior and should be considered in future cardiac modeling studies.
American Psychological Association (APA)
Zhan, Heqing& Xia, Ling. 2013. Excitation-Contraction Coupling between Human Atrial Myocytes with Fibroblasts and Stretch Activated Channel Current : A Simulation Study. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-456379
Modern Language Association (MLA)
Zhan, Heqing& Xia, Ling. Excitation-Contraction Coupling between Human Atrial Myocytes with Fibroblasts and Stretch Activated Channel Current : A Simulation Study. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-456379
American Medical Association (AMA)
Zhan, Heqing& Xia, Ling. Excitation-Contraction Coupling between Human Atrial Myocytes with Fibroblasts and Stretch Activated Channel Current : A Simulation Study. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-456379
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456379