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A Functional Polymorphism of the MAOA Gene Modulates Spontaneous Brain Activity in Pons
المؤلفون المشاركون
Yao, Shuqiao
Jiang, Yali
Rao, Hengyi
Gao, Yidian
Yi, Jinyao
Lei, Hui
Guo, Xiao
Zhang, Jibiao
Zhang, Xiaocui
Ming, Qingsen
Di, Xin
Zhu, Xiongzhao
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-25
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the effects of a functional polymorphism of the monoamine oxidase A (MAOA) gene on spontaneous brain activity in healthy male adolescents.
Methods.
Thirty-one healthy male adolescents with the low-activity MAOA genotype (MAOA-L) and 25 healthy male adolescents with the high-activity MAOA genotype (MAOA-H) completed the 11-item Barratt Impulsiveness Scale (BIS-11) questionnaire and were subjected to resting-state functional magnetic resonance imaging (rs-fMRI) scans.
The amplitude of low-frequency fluctuation (ALFF) of the blood oxygen level-dependent (BOLD) signal was calculated using REST software.
ALFF data were related to BIS scores and compared between genotype groups.
Results.
Compared with the MAOA-H group, the MAOA-L group showed significantly lower ALFFs in the pons.
There was a significant correlation between the BIS scores and the ALFF values in the pons for MAOA-L group, but not for the MAOA-H group.
Further regression analysis showed a significant genotype by ALFF values interaction effect on BIS scores.
Conclusions.
Lower spontaneous brain activity in the pons of the MAOA-L male adolescents may provide a neural mechanism by which boys with the MAOA-L genotype confers risk for impulsivity and aggression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lei, Hui& Zhang, Xiaocui& Di, Xin& Rao, Hengyi& Ming, Qingsen& Zhang, Jibiao…[et al.]. 2014. A Functional Polymorphism of the MAOA Gene Modulates Spontaneous Brain Activity in Pons. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-456786
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lei, Hui…[et al.]. A Functional Polymorphism of the MAOA Gene Modulates Spontaneous Brain Activity in Pons. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-456786
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lei, Hui& Zhang, Xiaocui& Di, Xin& Rao, Hengyi& Ming, Qingsen& Zhang, Jibiao…[et al.]. A Functional Polymorphism of the MAOA Gene Modulates Spontaneous Brain Activity in Pons. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-456786
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456786
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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