![](/images/graphics-bg.png)
A Functional Polymorphism of the MAOA Gene Modulates Spontaneous Brain Activity in Pons
Joint Authors
Yao, Shuqiao
Jiang, Yali
Rao, Hengyi
Gao, Yidian
Yi, Jinyao
Lei, Hui
Guo, Xiao
Zhang, Jibiao
Zhang, Xiaocui
Ming, Qingsen
Di, Xin
Zhu, Xiongzhao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To investigate the effects of a functional polymorphism of the monoamine oxidase A (MAOA) gene on spontaneous brain activity in healthy male adolescents.
Methods.
Thirty-one healthy male adolescents with the low-activity MAOA genotype (MAOA-L) and 25 healthy male adolescents with the high-activity MAOA genotype (MAOA-H) completed the 11-item Barratt Impulsiveness Scale (BIS-11) questionnaire and were subjected to resting-state functional magnetic resonance imaging (rs-fMRI) scans.
The amplitude of low-frequency fluctuation (ALFF) of the blood oxygen level-dependent (BOLD) signal was calculated using REST software.
ALFF data were related to BIS scores and compared between genotype groups.
Results.
Compared with the MAOA-H group, the MAOA-L group showed significantly lower ALFFs in the pons.
There was a significant correlation between the BIS scores and the ALFF values in the pons for MAOA-L group, but not for the MAOA-H group.
Further regression analysis showed a significant genotype by ALFF values interaction effect on BIS scores.
Conclusions.
Lower spontaneous brain activity in the pons of the MAOA-L male adolescents may provide a neural mechanism by which boys with the MAOA-L genotype confers risk for impulsivity and aggression.
American Psychological Association (APA)
Lei, Hui& Zhang, Xiaocui& Di, Xin& Rao, Hengyi& Ming, Qingsen& Zhang, Jibiao…[et al.]. 2014. A Functional Polymorphism of the MAOA Gene Modulates Spontaneous Brain Activity in Pons. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-456786
Modern Language Association (MLA)
Lei, Hui…[et al.]. A Functional Polymorphism of the MAOA Gene Modulates Spontaneous Brain Activity in Pons. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-456786
American Medical Association (AMA)
Lei, Hui& Zhang, Xiaocui& Di, Xin& Rao, Hengyi& Ming, Qingsen& Zhang, Jibiao…[et al.]. A Functional Polymorphism of the MAOA Gene Modulates Spontaneous Brain Activity in Pons. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-456786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456786