Recurrence of a t(8;21)-Positive Acute Myeloid Leukemia in the Form of a Granulocytic Sarcoma Involving Cranial Bones : A Diagnostic and Therapeutic Challenge
المؤلفون المشاركون
Ottaviani, Fabrizio
Ceresoli, Eleonora
Micarelli, Alessandro
Amadori, Sergio
Cefalo, Mariagiovanna
Nasso, Daniela
Di Veroli, Ambra
Venditti, Adriano
Cicconi, Laura
Mauramati, Simone
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-12
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Granulocytic sarcoma (GS) is a rare extramedullary solid tumor defined as an accumulation of myeloblasts or immature myeloid cells.
It can cooccur with or precede the acute myeloid leukemia (AML) as well as following treated AML.
The incidence of GS in AML patients is 3–8% but it significantly rises in M2 FAB subtype AML.
This variety of AML harbors t(8;21) in up to 20–25% of cases (especially in children and black ones of African origin) and, at a molecular level, it is characterized by the generation of a fusion gene known as RUNX1-RUNX1T1.
Approximately 10% of M2 AML patients will develop GS, as a consequence, the t(8;21) and the relative transcript represent the most common cytogenetic and molecular abnormalities in GS.
FLT3-ITD mutation was rarely described in AML patients presenting with GS.
FLT3 ITD is generally strongly associated with poor prognosis in AML, and is rarely reported in patients with t(8;21).
GS presentation is extremely variable depending on organs involved; in general, cranial bones and sinus are very rarely affected sites.
We report a rare case of GS occurring as a recurrence of a previously treated t(8;21), FLT3-ITD positive AML, involving mastoid bones and paravertebral tissues.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Di Veroli, Ambra& Micarelli, Alessandro& Cefalo, Mariagiovanna& Ceresoli, Eleonora& Nasso, Daniela& Cicconi, Laura…[et al.]. 2013. Recurrence of a t(8;21)-Positive Acute Myeloid Leukemia in the Form of a Granulocytic Sarcoma Involving Cranial Bones : A Diagnostic and Therapeutic Challenge. Case Reports in Hematology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-456900
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Di Veroli, Ambra…[et al.]. Recurrence of a t(8;21)-Positive Acute Myeloid Leukemia in the Form of a Granulocytic Sarcoma Involving Cranial Bones : A Diagnostic and Therapeutic Challenge. Case Reports in Hematology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-456900
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Di Veroli, Ambra& Micarelli, Alessandro& Cefalo, Mariagiovanna& Ceresoli, Eleonora& Nasso, Daniela& Cicconi, Laura…[et al.]. Recurrence of a t(8;21)-Positive Acute Myeloid Leukemia in the Form of a Granulocytic Sarcoma Involving Cranial Bones : A Diagnostic and Therapeutic Challenge. Case Reports in Hematology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-456900
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456900
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر