Recurrence of a t(8;21)-Positive Acute Myeloid Leukemia in the Form of a Granulocytic Sarcoma Involving Cranial Bones : A Diagnostic and Therapeutic Challenge
Joint Authors
Ottaviani, Fabrizio
Ceresoli, Eleonora
Micarelli, Alessandro
Amadori, Sergio
Cefalo, Mariagiovanna
Nasso, Daniela
Di Veroli, Ambra
Venditti, Adriano
Cicconi, Laura
Mauramati, Simone
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Granulocytic sarcoma (GS) is a rare extramedullary solid tumor defined as an accumulation of myeloblasts or immature myeloid cells.
It can cooccur with or precede the acute myeloid leukemia (AML) as well as following treated AML.
The incidence of GS in AML patients is 3–8% but it significantly rises in M2 FAB subtype AML.
This variety of AML harbors t(8;21) in up to 20–25% of cases (especially in children and black ones of African origin) and, at a molecular level, it is characterized by the generation of a fusion gene known as RUNX1-RUNX1T1.
Approximately 10% of M2 AML patients will develop GS, as a consequence, the t(8;21) and the relative transcript represent the most common cytogenetic and molecular abnormalities in GS.
FLT3-ITD mutation was rarely described in AML patients presenting with GS.
FLT3 ITD is generally strongly associated with poor prognosis in AML, and is rarely reported in patients with t(8;21).
GS presentation is extremely variable depending on organs involved; in general, cranial bones and sinus are very rarely affected sites.
We report a rare case of GS occurring as a recurrence of a previously treated t(8;21), FLT3-ITD positive AML, involving mastoid bones and paravertebral tissues.
American Psychological Association (APA)
Di Veroli, Ambra& Micarelli, Alessandro& Cefalo, Mariagiovanna& Ceresoli, Eleonora& Nasso, Daniela& Cicconi, Laura…[et al.]. 2013. Recurrence of a t(8;21)-Positive Acute Myeloid Leukemia in the Form of a Granulocytic Sarcoma Involving Cranial Bones : A Diagnostic and Therapeutic Challenge. Case Reports in Hematology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-456900
Modern Language Association (MLA)
Di Veroli, Ambra…[et al.]. Recurrence of a t(8;21)-Positive Acute Myeloid Leukemia in the Form of a Granulocytic Sarcoma Involving Cranial Bones : A Diagnostic and Therapeutic Challenge. Case Reports in Hematology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-456900
American Medical Association (AMA)
Di Veroli, Ambra& Micarelli, Alessandro& Cefalo, Mariagiovanna& Ceresoli, Eleonora& Nasso, Daniela& Cicconi, Laura…[et al.]. Recurrence of a t(8;21)-Positive Acute Myeloid Leukemia in the Form of a Granulocytic Sarcoma Involving Cranial Bones : A Diagnostic and Therapeutic Challenge. Case Reports in Hematology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-456900
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456900