Cathepsin D Expression in Colorectal Cancer : From Proteomic Discovery through Validation Using Western Blotting, Immunohistochemistry, and Tissue Microarrays
المؤلفون المشاركون
Bethwaite, Peter
Miller, Rose
Hayes, Mark
Jordan, T. William
Shi, Hongjun
Keating, John
Hood, Kylie
Kirana, Chandra
Stubbs, Richard S.
Laing, Emma
المصدر
International Journal of Proteomics
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Despite recent advances in surgical techniques and therapeutic treatments, survival from colorectal cancer (CRC) remains disappointing with some 40–50% of newly diagnosed patients ultimately dying of metastatic disease.
Current staging by light microscopy alone is not sufficiently predictive of prognosis and would benefit from additional support from biomarkers in order to stratify patients appropriately for adjuvant therapy.
We have identified that cathepsin D expression was significantly greater in cells from invasive front (IF) area and liver metastasis (LM) than those from main tumour body (MTB).
Cathepsin D expression was subsequently examined by immunohistochemistry in tissue microarrays from 119 patients with CRC.
Strong expression in tumour cells at the IF did not correlate significantly with any clinico-pathological parameters examined or patient survival.
However, cathepsin D expression in cells from the MTB was highly elevated in late stage CRC and showed significant correlation with subsequent distant metastasis and shorter cancer-specific survival.
We also found that macrophages surrounding tumour cells stained strongly for cathepsin D but there was no significant correlation found between cathepsin D in macrophages at IF and MTB of CRC patient with the clinic-pathological parameters examined.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kirana, Chandra& Shi, Hongjun& Laing, Emma& Hood, Kylie& Miller, Rose& Bethwaite, Peter…[et al.]. 2012. Cathepsin D Expression in Colorectal Cancer : From Proteomic Discovery through Validation Using Western Blotting, Immunohistochemistry, and Tissue Microarrays. International Journal of Proteomics،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-456942
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kirana, Chandra…[et al.]. Cathepsin D Expression in Colorectal Cancer : From Proteomic Discovery through Validation Using Western Blotting, Immunohistochemistry, and Tissue Microarrays. International Journal of Proteomics No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-456942
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kirana, Chandra& Shi, Hongjun& Laing, Emma& Hood, Kylie& Miller, Rose& Bethwaite, Peter…[et al.]. Cathepsin D Expression in Colorectal Cancer : From Proteomic Discovery through Validation Using Western Blotting, Immunohistochemistry, and Tissue Microarrays. International Journal of Proteomics. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-456942
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456942
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر