Neutrophil Inhibitory Factor Selectively Inhibits the Endothelium-Driven Transmigration of Eosinophils In Vitro and Airway Eosinophilia in OVA-Induced Allergic Lung Inflammation
المؤلفون المشاركون
Schnyder, Bruno
Moser, René
Schnyder-Candrian, Silvia
Maillet, Isabelle
Ryffel, Bernhard
Jacobs, Muazzam
Le Bert, Marc
Brault, Lea
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Leukocyte adhesion molecules are involved in cell recruitment in an allergic airway response and therefore provide a target for pharmaceutical intervention.
Neutrophil inhibitory factor (NIF), derived from canine hookworm (Ancylostoma caninum), binds selectively and competes with the A-domain of CD11b for binding to ICAM-1.
The effect of recombinant NIF was investigated.
Intranasal administration of rNIF reduced pulmonary eosinophilic infiltration, goblet cell hyperplasia, and Th2 cytokine production in OVA-sensitized mice.
In vitro, transendothelial migration of human blood eosinophils across IL-4-activated umbilical vein endothelial cell (HUVEC) monolayers was inhibited by rNIF (IC50: 4.6±2.6 nM; mean ± SEM), but not across TNF or IL-1-activated HUVEC monolayers.
Treatment of eosinophils with rNIF together with mAb 60.1 directed against CD11b or mAb 107 directed against the metal ion-dependent adhesion site (MIDAS) of the CD11b A-domain resulted in no further inhibition of transendothelial migration suggesting shared functional epitopes.
In contrast, rNIF increased the inhibitory effect of blocking mAbs against CD18, CD11a, and VLA-4.
Together, we show that rNIF, a selective antagonist of the A-domain of CD11b, has a prominent inhibitory effect on eosinophil transendothelial migration in vitro, which is congruent to the in vivo inhibition of OVA-induced allergic lung inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schnyder-Candrian, Silvia& Maillet, Isabelle& Le Bert, Marc& Brault, Lea& Jacobs, Muazzam& Ryffel, Bernhard…[et al.]. 2012. Neutrophil Inhibitory Factor Selectively Inhibits the Endothelium-Driven Transmigration of Eosinophils In Vitro and Airway Eosinophilia in OVA-Induced Allergic Lung Inflammation. Journal of Allergy،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-456955
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schnyder-Candrian, Silvia…[et al.]. Neutrophil Inhibitory Factor Selectively Inhibits the Endothelium-Driven Transmigration of Eosinophils In Vitro and Airway Eosinophilia in OVA-Induced Allergic Lung Inflammation. Journal of Allergy No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-456955
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schnyder-Candrian, Silvia& Maillet, Isabelle& Le Bert, Marc& Brault, Lea& Jacobs, Muazzam& Ryffel, Bernhard…[et al.]. Neutrophil Inhibitory Factor Selectively Inhibits the Endothelium-Driven Transmigration of Eosinophils In Vitro and Airway Eosinophilia in OVA-Induced Allergic Lung Inflammation. Journal of Allergy. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-456955
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456955
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر