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Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis
المؤلفون المشاركون
Firozgary, Bahrom
Bulsara, Tushar
Bhatena, Zal
Weinstock, Joel
Robinson, Prema
Tweardy, David John
Siller, Ricardo
Firozgary, Gohar
Khumbatta, Mitra
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-08
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Cysticercosis is an infection of tissues with the larval cysts of the cestode, Taenia solium.
While live parasites elicit little or no inflammation, dying parasites initiate a granulomatous reaction presenting as painful muscle nodules or seizures when cysts are located in the brain.
We previously showed in the T.
crassiceps murine model of cysticercosis that substance P (SP), a neuropeptide, was detected in early granulomas and was responsible for promoting granuloma formation, while somatostatin (SOM), another neuropeptide and immunomodulatory hormone, was detected in late granulomas; SOM’s contribution to granuloma formation was not examined.
In the current studies, we used somatostatin knockout (SOM−/−) mice to examine the hypothesis that SOM downmodulates granulomatous inflammation in cysticercosis, thereby promoting parasite growth.
Our results demonstrated that parasite burden was reduced 5.9-fold in SOM−/− mice compared to WT mice (P<0.05).
This reduction in parasite burden in SOM−/− mice was accompanied by a 95% increase in size of their granulomas (P<0.05), which contained a 1.5-fold increase in levels of IFN-γ and a 26-fold decrease in levels of IL-1β (P<0.05 for both) compared to granulomas from WT mice.
Thus, SOM regulates both parasite burden and granulomatous inflammation perhaps through modulating granuloma production of IFN-γ and IL-1β.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khumbatta, Mitra& Firozgary, Bahrom& Tweardy, David John& Weinstock, Joel& Firozgary, Gohar& Bhatena, Zal…[et al.]. 2014. Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-457071
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khumbatta, Mitra…[et al.]. Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-457071
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khumbatta, Mitra& Firozgary, Bahrom& Tweardy, David John& Weinstock, Joel& Firozgary, Gohar& Bhatena, Zal…[et al.]. Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-457071
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-457071
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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