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Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis
Joint Authors
Firozgary, Bahrom
Bulsara, Tushar
Bhatena, Zal
Weinstock, Joel
Robinson, Prema
Tweardy, David John
Siller, Ricardo
Firozgary, Gohar
Khumbatta, Mitra
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cysticercosis is an infection of tissues with the larval cysts of the cestode, Taenia solium.
While live parasites elicit little or no inflammation, dying parasites initiate a granulomatous reaction presenting as painful muscle nodules or seizures when cysts are located in the brain.
We previously showed in the T.
crassiceps murine model of cysticercosis that substance P (SP), a neuropeptide, was detected in early granulomas and was responsible for promoting granuloma formation, while somatostatin (SOM), another neuropeptide and immunomodulatory hormone, was detected in late granulomas; SOM’s contribution to granuloma formation was not examined.
In the current studies, we used somatostatin knockout (SOM−/−) mice to examine the hypothesis that SOM downmodulates granulomatous inflammation in cysticercosis, thereby promoting parasite growth.
Our results demonstrated that parasite burden was reduced 5.9-fold in SOM−/− mice compared to WT mice (P<0.05).
This reduction in parasite burden in SOM−/− mice was accompanied by a 95% increase in size of their granulomas (P<0.05), which contained a 1.5-fold increase in levels of IFN-γ and a 26-fold decrease in levels of IL-1β (P<0.05 for both) compared to granulomas from WT mice.
Thus, SOM regulates both parasite burden and granulomatous inflammation perhaps through modulating granuloma production of IFN-γ and IL-1β.
American Psychological Association (APA)
Khumbatta, Mitra& Firozgary, Bahrom& Tweardy, David John& Weinstock, Joel& Firozgary, Gohar& Bhatena, Zal…[et al.]. 2014. Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-457071
Modern Language Association (MLA)
Khumbatta, Mitra…[et al.]. Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-457071
American Medical Association (AMA)
Khumbatta, Mitra& Firozgary, Bahrom& Tweardy, David John& Weinstock, Joel& Firozgary, Gohar& Bhatena, Zal…[et al.]. Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-457071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457071