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Neuromodulatory Effects of Hesperidin in Mitigating Oxidative Stress in Streptozotocin Induced Diabetes
المؤلفون المشاركون
Wajid, Saima
Parvez, Suhel
Khan, Mohammad Haaris Ajmal
Naseem, Mehar
Salman, Mohd.
Varshney, Laxmi
Ashafaq, Mohammad
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Oxidative stress has been implicated in pathogenesis of streptozotocin- (STZ-) induced diabetes mellitus and its complication in central nervous system (CNS).
Recent studies have provided insights on antioxidants and their emergence as potential therapeutic and nutraceutical.
The present study examined the hypothesis that hesperidin (HP) ameliorates oxidative stress and may be a limiting factor in the extent of CNS complication following diabetes.
To test this hypothesis rats were divided into four groups: control, diabetic, diabetic-HP treated, and vehicle for HP treatment group.
Diabetes mellitus was induced by a single injection of STZ (65 mg/kg body weight).
Three days after STZ injection, HP was given (50 mg/kg b.wt.
orally) once daily for four weeks.
The results of the present investigation suggest that the significant elevated levels of oxidative stress markers were observed in STZ-treated animals, whereas significant depletion in the activity of nonenzymatic antioxidants and enzymatic antioxidants was witnessed in diabetic rat brain.
Neurotoxicity biomarker activity was also altered significantly.
HP treatment significantly attenuated the altered levels of oxidative stress and neurotoxicity biomarkers.
Our results demonstrate that HP exhibits potent antioxidant and neuroprotective effects on the brain tissue against the diabetic oxidative damage in STZ-induced rodent model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ashafaq, Mohammad& Varshney, Laxmi& Khan, Mohammad Haaris Ajmal& Salman, Mohd.& Naseem, Mehar& Wajid, Saima…[et al.]. 2014. Neuromodulatory Effects of Hesperidin in Mitigating Oxidative Stress in Streptozotocin Induced Diabetes. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-457254
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ashafaq, Mohammad…[et al.]. Neuromodulatory Effects of Hesperidin in Mitigating Oxidative Stress in Streptozotocin Induced Diabetes. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-457254
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ashafaq, Mohammad& Varshney, Laxmi& Khan, Mohammad Haaris Ajmal& Salman, Mohd.& Naseem, Mehar& Wajid, Saima…[et al.]. Neuromodulatory Effects of Hesperidin in Mitigating Oxidative Stress in Streptozotocin Induced Diabetes. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-457254
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-457254
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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