Neuromodulatory Effects of Hesperidin in Mitigating Oxidative Stress in Streptozotocin Induced Diabetes
Joint Authors
Wajid, Saima
Parvez, Suhel
Khan, Mohammad Haaris Ajmal
Naseem, Mehar
Salman, Mohd.
Varshney, Laxmi
Ashafaq, Mohammad
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oxidative stress has been implicated in pathogenesis of streptozotocin- (STZ-) induced diabetes mellitus and its complication in central nervous system (CNS).
Recent studies have provided insights on antioxidants and their emergence as potential therapeutic and nutraceutical.
The present study examined the hypothesis that hesperidin (HP) ameliorates oxidative stress and may be a limiting factor in the extent of CNS complication following diabetes.
To test this hypothesis rats were divided into four groups: control, diabetic, diabetic-HP treated, and vehicle for HP treatment group.
Diabetes mellitus was induced by a single injection of STZ (65 mg/kg body weight).
Three days after STZ injection, HP was given (50 mg/kg b.wt.
orally) once daily for four weeks.
The results of the present investigation suggest that the significant elevated levels of oxidative stress markers were observed in STZ-treated animals, whereas significant depletion in the activity of nonenzymatic antioxidants and enzymatic antioxidants was witnessed in diabetic rat brain.
Neurotoxicity biomarker activity was also altered significantly.
HP treatment significantly attenuated the altered levels of oxidative stress and neurotoxicity biomarkers.
Our results demonstrate that HP exhibits potent antioxidant and neuroprotective effects on the brain tissue against the diabetic oxidative damage in STZ-induced rodent model.
American Psychological Association (APA)
Ashafaq, Mohammad& Varshney, Laxmi& Khan, Mohammad Haaris Ajmal& Salman, Mohd.& Naseem, Mehar& Wajid, Saima…[et al.]. 2014. Neuromodulatory Effects of Hesperidin in Mitigating Oxidative Stress in Streptozotocin Induced Diabetes. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-457254
Modern Language Association (MLA)
Ashafaq, Mohammad…[et al.]. Neuromodulatory Effects of Hesperidin in Mitigating Oxidative Stress in Streptozotocin Induced Diabetes. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-457254
American Medical Association (AMA)
Ashafaq, Mohammad& Varshney, Laxmi& Khan, Mohammad Haaris Ajmal& Salman, Mohd.& Naseem, Mehar& Wajid, Saima…[et al.]. Neuromodulatory Effects of Hesperidin in Mitigating Oxidative Stress in Streptozotocin Induced Diabetes. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-457254
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457254