Synthesis and Evaluation of Novel Pyrroles and Pyrrolopyrimidines as Anti-Hyperglycemic Agents

الملخص EN

A series of pyrrole and pyrrolopyrimidine derivatives were examined for their in vivo antihyperglycemic activity.

Compounds Ia–c,e, and IVg showed promising antihyperglycemic activity equivalent to a well-known standard antihyperglycemic drug, Glimepiride (Amaryl, 4 mg/kg).

In this paper, we examine and discuss the structure-activity relationships and antihyperglycemic activity of these compounds.