Novel Intriguing Strategies Attenuating to Sarcopenia

المؤلفون المشاركون

Yamaguchi, Akihiko
Sakuma, Kunihiro

المصدر

Journal of Aging Research

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-02-20

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

العلوم الطبية والصيدلة والعلوم الصحية

الملخص EN

Sarcopenia, the age-related loss of skeletal muscle mass, is characterized by a deterioration of muscle quantity and quality leading to a gradual slowing of movement, a decline in strength and power, increased risk of fall-related injury, and, often, frailty.

Since sarcopenia is largely attributed to various molecular mediators affecting fiber size, mitochondrial homeostasis, and apoptosis, the mechanisms responsible for these deleterious changes present numerous therapeutic targets for drug discovery.

Resistance training combined with amino acid-containing supplements is often utilized to prevent age-related muscle wasting and weakness.

In this review, we summarize more recent therapeutic strategies (myostatin or proteasome inhibition, supplementation with eicosapentaenoic acid (EPA) or ursolic acid, etc.) for counteracting sarcopenia.

Myostatin inhibitor is the most advanced research with a Phase I/II trial in muscular dystrophy but does not try the possibility for attenuating sarcopenia.

EPA and ursolic acid seem to be effective as therapeutic agents, because they attenuate the degenerative symptoms of muscular dystrophy and cachexic muscle.

The activation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) in skeletal muscle by exercise and/or unknown supplementation would be an intriguing approach to attenuating sarcopenia.

In contrast, muscle loss with age may not be influenced positively by treatment with a proteasome inhibitor or antioxidant.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Sakuma, Kunihiro& Yamaguchi, Akihiko. 2012. Novel Intriguing Strategies Attenuating to Sarcopenia. Journal of Aging Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-457463

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Sakuma, Kunihiro& Yamaguchi, Akihiko. Novel Intriguing Strategies Attenuating to Sarcopenia. Journal of Aging Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-457463

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Sakuma, Kunihiro& Yamaguchi, Akihiko. Novel Intriguing Strategies Attenuating to Sarcopenia. Journal of Aging Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-457463

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-457463