Novel Intriguing Strategies Attenuating to Sarcopenia
Joint Authors
Yamaguchi, Akihiko
Sakuma, Kunihiro
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Sarcopenia, the age-related loss of skeletal muscle mass, is characterized by a deterioration of muscle quantity and quality leading to a gradual slowing of movement, a decline in strength and power, increased risk of fall-related injury, and, often, frailty.
Since sarcopenia is largely attributed to various molecular mediators affecting fiber size, mitochondrial homeostasis, and apoptosis, the mechanisms responsible for these deleterious changes present numerous therapeutic targets for drug discovery.
Resistance training combined with amino acid-containing supplements is often utilized to prevent age-related muscle wasting and weakness.
In this review, we summarize more recent therapeutic strategies (myostatin or proteasome inhibition, supplementation with eicosapentaenoic acid (EPA) or ursolic acid, etc.) for counteracting sarcopenia.
Myostatin inhibitor is the most advanced research with a Phase I/II trial in muscular dystrophy but does not try the possibility for attenuating sarcopenia.
EPA and ursolic acid seem to be effective as therapeutic agents, because they attenuate the degenerative symptoms of muscular dystrophy and cachexic muscle.
The activation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) in skeletal muscle by exercise and/or unknown supplementation would be an intriguing approach to attenuating sarcopenia.
In contrast, muscle loss with age may not be influenced positively by treatment with a proteasome inhibitor or antioxidant.
American Psychological Association (APA)
Sakuma, Kunihiro& Yamaguchi, Akihiko. 2012. Novel Intriguing Strategies Attenuating to Sarcopenia. Journal of Aging Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-457463
Modern Language Association (MLA)
Sakuma, Kunihiro& Yamaguchi, Akihiko. Novel Intriguing Strategies Attenuating to Sarcopenia. Journal of Aging Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-457463
American Medical Association (AMA)
Sakuma, Kunihiro& Yamaguchi, Akihiko. Novel Intriguing Strategies Attenuating to Sarcopenia. Journal of Aging Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-457463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457463