Protein Tau : Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease
المؤلفون المشاركون
Van Leuven, Fred
Theunis, Clara
Crespo-Biel, Natalia
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-08
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The microtubule-associated protein Tau (MAPT) is a major component of the pathogenesis of a wide variety of brain-damaging disorders, known as tauopathies.
These include Alzheimer's disease (AD), denoted as secondary tauopathy because of the obligatory combination with amyloid pathology.
In all tauopathies, protein Tau becomes aberrantly phosphorylated, adopts abnormal conformations, and aggregates into fibrils that eventually accumulate as threads in neuropil and as tangles in soma.
The argyrophilic neurofibrillary threads and tangles, together denoted as NFT, provide the postmortem pathological diagnosis for all tauopathies.
In AD, neurofibrillary threads and tangles (NFTs) are codiagnostic with amyloid depositions but their separated and combined contributions to clinical symptoms remain elusive.
Importantly, NFTs are now considered a late event and not directly responsible for early synaptic dysfunctions.
Conversely, the biochemical and pathological timeline is not exactly known in human tauopathy, but experimental models point to smaller Tau-aggregates, termed oligomers or multimers, as synaptotoxic in early stages.
The challenge is to molecularly define these Tau-isoforms that cause early cognitive and synaptic impairments.
Here, we discuss relevant studies and data obtained in our mono- and bigenic validated preclinical models, with the perspective of Tau as a therapeutic target.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Crespo-Biel, Natalia& Theunis, Clara& Van Leuven, Fred. 2012. Protein Tau : Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-457483
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Crespo-Biel, Natalia…[et al.]. Protein Tau : Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-457483
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Crespo-Biel, Natalia& Theunis, Clara& Van Leuven, Fred. Protein Tau : Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-457483
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-457483
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر