Protein Tau : Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease
Joint Authors
Van Leuven, Fred
Theunis, Clara
Crespo-Biel, Natalia
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The microtubule-associated protein Tau (MAPT) is a major component of the pathogenesis of a wide variety of brain-damaging disorders, known as tauopathies.
These include Alzheimer's disease (AD), denoted as secondary tauopathy because of the obligatory combination with amyloid pathology.
In all tauopathies, protein Tau becomes aberrantly phosphorylated, adopts abnormal conformations, and aggregates into fibrils that eventually accumulate as threads in neuropil and as tangles in soma.
The argyrophilic neurofibrillary threads and tangles, together denoted as NFT, provide the postmortem pathological diagnosis for all tauopathies.
In AD, neurofibrillary threads and tangles (NFTs) are codiagnostic with amyloid depositions but their separated and combined contributions to clinical symptoms remain elusive.
Importantly, NFTs are now considered a late event and not directly responsible for early synaptic dysfunctions.
Conversely, the biochemical and pathological timeline is not exactly known in human tauopathy, but experimental models point to smaller Tau-aggregates, termed oligomers or multimers, as synaptotoxic in early stages.
The challenge is to molecularly define these Tau-isoforms that cause early cognitive and synaptic impairments.
Here, we discuss relevant studies and data obtained in our mono- and bigenic validated preclinical models, with the perspective of Tau as a therapeutic target.
American Psychological Association (APA)
Crespo-Biel, Natalia& Theunis, Clara& Van Leuven, Fred. 2012. Protein Tau : Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-457483
Modern Language Association (MLA)
Crespo-Biel, Natalia…[et al.]. Protein Tau : Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-457483
American Medical Association (AMA)
Crespo-Biel, Natalia& Theunis, Clara& Van Leuven, Fred. Protein Tau : Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-457483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457483