Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer
المؤلفون المشاركون
Torkelson, Carolyn J.
Wenner, Cynthia A.
Sweet, Erin
Sasagawa, Masa
Gay, Juliette
Putiri, Amy
Standish, Leanna J.
Martzen, Mark R.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
Orally administered preparations from the Trametes versicolor (Tv) mushroom have been hypothesized to improve immune response in women with breast cancer after standard chemotherapy and radiotherapy.
Methods.
A phase I, two-center, dose escalation study was done to determine the maximum tolerated dose of a Tv preparation when taken daily in divided doses for 6 weeks after recent completion of radiotherapy.
Eleven participants were recruited and nine women completed the study.
Each cohort was comprised of three participants given one of three doses of Tv (3, 6, or 9 grams).
Immune data was collected pre- and postradiation, at 3 on-treatment time points and after a 3-week washout.
Results.
Nine adverse events were reported (7 mild, 1 moderate, and 1 severe), suggesting that Tv was well tolerated.
Immunological results indicated trends in (1) increased lymphocyte counts at 6 and 9 grams/day; (2) increased natural killer cell functional activity at 6 grams/day; (3) dose-related increases in CD8+ T cells and CD19+ B cells , but not CD4+ T cells or CD16+56+ NK cells.
Conclusion.
These findings show that up to 9 grams/day of a Tv preparation is safe and tolerable in women with breast cancer in the postprimary treatment setting.
This Tv preparation may improve immune status in immunocompromised breast cancer patients following standard primary oncologic treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Torkelson, Carolyn J.& Sweet, Erin& Martzen, Mark R.& Sasagawa, Masa& Wenner, Cynthia A.& Gay, Juliette…[et al.]. 2012. Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer. ISRN Oncology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-457510
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Torkelson, Carolyn J.…[et al.]. Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer. ISRN Oncology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-457510
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Torkelson, Carolyn J.& Sweet, Erin& Martzen, Mark R.& Sasagawa, Masa& Wenner, Cynthia A.& Gay, Juliette…[et al.]. Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-457510
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-457510
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر