Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer
Joint Authors
Torkelson, Carolyn J.
Wenner, Cynthia A.
Sweet, Erin
Sasagawa, Masa
Gay, Juliette
Putiri, Amy
Standish, Leanna J.
Martzen, Mark R.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Orally administered preparations from the Trametes versicolor (Tv) mushroom have been hypothesized to improve immune response in women with breast cancer after standard chemotherapy and radiotherapy.
Methods.
A phase I, two-center, dose escalation study was done to determine the maximum tolerated dose of a Tv preparation when taken daily in divided doses for 6 weeks after recent completion of radiotherapy.
Eleven participants were recruited and nine women completed the study.
Each cohort was comprised of three participants given one of three doses of Tv (3, 6, or 9 grams).
Immune data was collected pre- and postradiation, at 3 on-treatment time points and after a 3-week washout.
Results.
Nine adverse events were reported (7 mild, 1 moderate, and 1 severe), suggesting that Tv was well tolerated.
Immunological results indicated trends in (1) increased lymphocyte counts at 6 and 9 grams/day; (2) increased natural killer cell functional activity at 6 grams/day; (3) dose-related increases in CD8+ T cells and CD19+ B cells , but not CD4+ T cells or CD16+56+ NK cells.
Conclusion.
These findings show that up to 9 grams/day of a Tv preparation is safe and tolerable in women with breast cancer in the postprimary treatment setting.
This Tv preparation may improve immune status in immunocompromised breast cancer patients following standard primary oncologic treatment.
American Psychological Association (APA)
Torkelson, Carolyn J.& Sweet, Erin& Martzen, Mark R.& Sasagawa, Masa& Wenner, Cynthia A.& Gay, Juliette…[et al.]. 2012. Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer. ISRN Oncology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-457510
Modern Language Association (MLA)
Torkelson, Carolyn J.…[et al.]. Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer. ISRN Oncology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-457510
American Medical Association (AMA)
Torkelson, Carolyn J.& Sweet, Erin& Martzen, Mark R.& Sasagawa, Masa& Wenner, Cynthia A.& Gay, Juliette…[et al.]. Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-457510
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457510