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Pu-Erh Tea Extract Induces the Degradation of FET Family Proteins Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis
المؤلفون المشاركون
Sheng, Jun
Shi, Wei
Hayashi, Shuhei
Fang, Chongye
Tsutsui, Hiroko
Yu, Yang
Cai, Xianbin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-07
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
FET family proteins consist of fused in sarcoma/translocated in liposarcoma (FUS/TLS), Ewing's sarcoma (EWS), and TATA-binding protein-associated factor 15 (TAF15).
Mutations in the copper/zinc superoxide dismutase (SOD1), TAR DNA-binding protein 43 (TDP-43), and FET family proteins are associated with the development of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease.
There is currently no cure for this disease and few effective treatments are available.
Epidemiological studies indicate that the consumption of tea is associated with a reduced risk of developing neurodegenerative diseases.
The results of this study revealed that components of a pu-erh tea extract (PTE) interacted with FET family proteins but not with TDP-43 or SOD1.
PTE induced the degradation of FET family proteins but had no effects on TDP-43 or SOD1.
The most frequently occurring ALS-linked FUS/TLS mutant protein, R521C FUS/TLS, was also degraded in the presence of PTE.
Furthermore, ammonium chloride, a lysosome inhibitor, but not lactacystin, a proteasome inhibitor, reduced the degradation of FUS/TLS protein by PTE.
PTE significantly reduced the incorporation of R521C FUS/TLS into stress granules under stress conditions.
These findings suggest that PTE may have beneficial health effects, including preventing the onset of FET family protein-associated neurodegenerative diseases and delaying the progression of ALS by inhibiting the cytoplasmic aggregation of FET family proteins.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Yang& Hayashi, Shuhei& Cai, Xianbin& Fang, Chongye& Shi, Wei& Tsutsui, Hiroko…[et al.]. 2014. Pu-Erh Tea Extract Induces the Degradation of FET Family Proteins Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-457780
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Yang…[et al.]. Pu-Erh Tea Extract Induces the Degradation of FET Family Proteins Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-457780
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Yang& Hayashi, Shuhei& Cai, Xianbin& Fang, Chongye& Shi, Wei& Tsutsui, Hiroko…[et al.]. Pu-Erh Tea Extract Induces the Degradation of FET Family Proteins Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-457780
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-457780
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